Document Detail

Verapamil-induced ventricular tachycardia in hypertrophic cardiomyopathy.
MedLine Citation:
PMID:  3582389     Owner:  NLM     Status:  MEDLINE    
A 17-year old boy with hypertrophic obstructive cardiomyopathy (HOCM) developed repeated short runs of self terminating ventricular tachycardia 12 hours after starting oral verapamil, which was substituted for propranolol therapy. It is suggested that alterations in sympathetic tone induced by changing from a beta-blocker to a calcium antagonist might have increased myocardial irritability thus favouring genesis of severe ventricular arrhythmias. Verapamil is often considered to be more effective than propranolol in the treatment of HOCM. However, if propranolol is replaced by verapamil one has to take account of the possibility of serious arrhythmias as demonstrated by our case.
A Wessel; P Seiffert; R Dettmann; P H Heintzen
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European heart journal     Volume:  8     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1987 Mar 
Date Detail:
Created Date:  1987-07-07     Completed Date:  1987-07-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  313-5     Citation Subset:  IM    
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MeSH Terms
Cardiomyopathy, Hypertrophic / drug therapy*
Tachycardia / chemically induced*
Verapamil / adverse effects*,  therapeutic use
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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