| Verapamil effects on left ventricular performance in patients with congestive heart failure studied with echocardiography before and after cardiac surgery. | |
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MedLine Citation:
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PMID: 3704598 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cardiac effects of a single dose of verapamil was studied with digitalization of M-mode echocardiograms in 6 patients before and after surgery, along with pharmacological examinations. Corresponding to the different distribution volume and excretion pre- and postoperatively, the cardiodepressive effect on the contraction of the left ventricle was more pronounced and lasted longer postoperatively. Probably due to initial reduction of peripheral resistance, there was an initial improvement of ventricular contractility indices. Obviously depending on serum concentration, maximal cardiodepression occurred at 35-40 ng/ml, and no effect could longer be found as the values reached 20 ng/ml, pre- as well as postoperatively. |
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Authors:
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P G Bjørnstad; L Storstein; B K Semb |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Scandinavian journal of thoracic and cardiovascular surgery Volume: 20 ISSN: 0036-5580 ISO Abbreviation: Scand J Thorac Cardiovasc Surg Publication Date: 1986 |
Date Detail:
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Created Date: 1986-06-02 Completed Date: 1986-06-02 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0121343 Medline TA: Scand J Thorac Cardiovasc Surg Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 61-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aortic Valve Insufficiency / complications, surgery Depression, Chemical Echocardiography Female Heart / drug effects* Heart Failure / etiology, physiopathology* Humans Kinetics Male Middle Aged Myocardial Contraction / drug effects Postoperative Period Preoperative Care Time Factors Verapamil / blood, diagnostic use* |
| Chemical | |
Reg. No./Substance:
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52-53-9/Verapamil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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