Document Detail


Verapamil effects on left ventricular performance in patients with congestive heart failure studied with echocardiography before and after cardiac surgery.
MedLine Citation:
PMID:  3704598     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardiac effects of a single dose of verapamil was studied with digitalization of M-mode echocardiograms in 6 patients before and after surgery, along with pharmacological examinations. Corresponding to the different distribution volume and excretion pre- and postoperatively, the cardiodepressive effect on the contraction of the left ventricle was more pronounced and lasted longer postoperatively. Probably due to initial reduction of peripheral resistance, there was an initial improvement of ventricular contractility indices. Obviously depending on serum concentration, maximal cardiodepression occurred at 35-40 ng/ml, and no effect could longer be found as the values reached 20 ng/ml, pre- as well as postoperatively.
Authors:
P G Bjørnstad; L Storstein; B K Semb
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of thoracic and cardiovascular surgery     Volume:  20     ISSN:  0036-5580     ISO Abbreviation:  Scand J Thorac Cardiovasc Surg     Publication Date:  1986  
Date Detail:
Created Date:  1986-06-02     Completed Date:  1986-06-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0121343     Medline TA:  Scand J Thorac Cardiovasc Surg     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  61-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aortic Valve Insufficiency / complications,  surgery
Depression, Chemical
Echocardiography
Female
Heart / drug effects*
Heart Failure / etiology,  physiopathology*
Humans
Kinetics
Male
Middle Aged
Myocardial Contraction / drug effects
Postoperative Period
Preoperative Care
Time Factors
Verapamil / blood,  diagnostic use*
Chemical
Reg. No./Substance:
52-53-9/Verapamil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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