| Ventrolateral medullary neurons projecting to the medial preoptic/anterior hypothalamic area through the medial forebrain bundle: an electrophysiological study in the rat. | |
| | |
MedLine Citation:
|
PMID: 3489639 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A total of 152 ventrolateral medullary neurons was antidromically stimulated from both the medial preoptic/anterior hypothalamic area (MPOAH) and the medial forebrain bundle (MFB) in urethane anesthetized rats. These neurons were located primarily dorsal to the lateral reticular nucleus and could be readily classified in at least two groups, type I and type II cells on the basis of electrophysiological properties. The action potentials of type I cells had a shorter duration, and their conduction velocities ranged from 0.45 to 3.1 m/s. By contrast, type II cells, most predominantly observed, were characterized by a longer duration and an unusual shape of their action potential, and the antidromic propagation into the somatodendritic complex was often blocked. The conduction velocity (mean = 0.21 m/s) and absolute refractory period (mean = 2.63 ms) of type II cells are consistent with them having fine non-myelinated axons. Injection of 6-hydroxydopamine (6-OHDA), but not 5,7-dihydroxytryptamine, directly into the MFB blocked antidromic responses of 57% of type II cells tested. The residual type II cells whose antidromic responses were not affected by 6-OHDA were located significantly rostral to the 6-OHDA sensitive cells. Neither antidromic response of type I cells tested, on the other hand, was affected by 6-OHDA. The majority of type I cells were dramatically activated by noxious pinches of the tail, whereas the noxious stimuli produced no detectable change in the firing of type II cells. These data demonstrate that ventrolateral medullary neurons projecting to the MPOAH through the MFB are comprised of at least three distinct populations: 6-OHDA resistant fast conducting cells with somatic afferents, 6-OHDA sensitive and resistant slow conducting cells. |
| | |
Authors:
|
H Kaba; H Saito; K Otsuka; K Seto |
Related Documents
:
|
21693179 - Protective effect of diazoxide against antimycin a-induced mitochondrial dysfunction in... 6875929 - Effects of exposure to lines of one or two orientations on different cell types in stri... 21825949 - Gender dimorphism in the gut: mucosal protection by estrogen stimulation of iga transcy... 21888019 - Effect of a chloride channel inhibitor, 5-nitro-2-(3-phenylpropylamino)-benzoate, on ov... 21783809 - Growth-promoting effect of environmental endocrine disruptors on human neuroblastoma sk... 1262559 - Cell growth in the lateral geniculate nucleus of kittens following the opening or closi... 9402219 - Ampa/kainate receptors modulate the survival in vitro of embryonic brainstem cells. 21191979 - Cellular uptake and imaging studies of gadolinium-loaded single-walled carbon nanotubes... 23517729 - Efficient induction of apoptosis in hela cells by a novel cationic porphycene photosens... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale Volume: 63 ISSN: 0014-4819 ISO Abbreviation: Exp Brain Res Publication Date: 1986 |
Date Detail:
|
Created Date: 1986-11-13 Completed Date: 1986-11-13 Revised Date: 2009-11-11 |
Medline Journal Info:
|
Nlm Unique ID: 0043312 Medline TA: Exp Brain Res Country: GERMANY, WEST |
Other Details:
|
Languages: eng Pagination: 369-74 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Action Potentials
/
drug effects Animals Electric Stimulation Electrophysiology Hydroxydopamines / pharmacology Hypothalamus / drug effects, physiology* Hypothalamus, Anterior / drug effects, physiology Hypothalamus, Middle / drug effects, physiology Male Medial Forebrain Bundle / drug effects, physiology* Medulla Oblongata / drug effects, physiology* Neural Conduction / drug effects Neural Pathways / physiology* Neurons / drug effects, physiology Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
|
0/Hydroxydopamines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Target cell for prostaglandin E in the stimulation of in vitro human erythroid (BFU-E) progenitor ce...
Next Document: Suppression of visually evoked postural responses.