Document Detail


Ventriculomegaly, delayed myelination, white matter hypoplasia, and "periventricular" leukomalacia: how are they related?
MedLine Citation:
PMID:  8888047     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Preterm infants, including some who have sustained intracranial hemorrhage, appear to be at increased risk of lateral ventricular enlargement. Although some occurrences might be due to an impairment of cerebrospinal fluid flow or absorption, many instances of ventriculomegaly without accompanying macrocephaly reflect diffuse white matter damage resulting in diminished (i.e., hypoplastic) white matter or an inadequate density of axons. Perinatally acquired widespread white matter damage is sometimes associated with the focal white matter necrosis. We hypothesize that in some infants both ventriculomegaly and delayed myelination are consequences of disturbances to myelinogenesis that result from an impairment of cells destined to become oligodendroglia or of disturbances to rapidly growing axons. The vulnerability of developing white matter in preterm newborns might, in part, reflect the diminished availability of growth/ survival factors, or a vulnerability to toxins or physiologic perturbations. Awareness that some ventriculomegaly reflects widely distributed white matter damage should prevent overtreatment of what might appear to be hydrocephalus, but is not due to impaired cerebrospinal fluid dynamics. Increased understanding of the phenomena leading to ventriculomegaly related to paucity of white matter should lead to successful efforts to prevent white matter damage in preterm newborns.
Authors:
A Leviton; F Gilles
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Pediatric neurology     Volume:  15     ISSN:  0887-8994     ISO Abbreviation:  Pediatr. Neurol.     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1997-02-21     Completed Date:  1997-02-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8508183     Medline TA:  Pediatr Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  127-36     Citation Subset:  IM    
Affiliation:
Neurology Department, Children's Hospital, Boston, MA 02115, USA.
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MeSH Terms
Descriptor/Qualifier:
Axons / pathology
Cerebral Hemorrhage / diagnosis,  mortality
Cerebral Ventricles / pathology*
Cerebrospinal Fluid / physiology
Humans
Hydrocephalus / diagnosis,  mortality
Hypertrophy
Infant, Newborn
Infant, Premature, Diseases / diagnosis*,  mortality
Leukomalacia, Periventricular / diagnosis*,  mortality
Nerve Fibers, Myelinated / pathology*
Prognosis
Survival Rate
Grant Support
ID/Acronym/Agency:
NS 27306/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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