Document Detail

Ventriculitis in newborns with myelomeningocele.
MedLine Citation:
PMID:  2003476     Owner:  NLM     Status:  MEDLINE    
It has frequently been cited that a delay in back closure of beyond age 48 hours in newborns with myelomeningocele is associated with an increased risk of ventriculitis. It has been suggested that antibiotic therapy prior to surgery might minimize this risk. We reviewed our experience with ventriculitis in newborns with myelomeningocele and its relationship to antibiotic usage and time of back closure. Of 186 newborns, ventriculitis developed in 13 (7%), and there was no observed difference by time of back closure, clinical severity of infant at birth, status of myelomeningocele sac at birth, or type of delivery. There was a significant association between antibiotic usage and ventriculitis among the infants with delayed surgery, of which only one (1%) of 73 receiving broad-spectrum antibiotic prophylactic therapy developed ventriculitis compared with five (19%) of the 27 who did not receive antibiotics. Our data support the suggestion that antibiotic treatment is effective in minimizing the risk of ventriculitis among infants with myelomeningocele undergoing surgery after 48 hours of age.
E B Charney; J B Melchionni; D L Antonucci
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  American journal of diseases of children (1960)     Volume:  145     ISSN:  0002-922X     ISO Abbreviation:  Am. J. Dis. Child.     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-04-12     Completed Date:  1991-04-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370471     Medline TA:  Am J Dis Child     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  287-90     Citation Subset:  AIM; IM    
Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use*
Bacterial Infections / etiology,  prevention & control*
Cerebral Ventricles*
Encephalitis / etiology,  prevention & control*
Infant, Newborn
Meningomyelocele / complications*,  surgery
Time Factors
Reg. No./Substance:
0/Anti-Bacterial Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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