Document Detail

Ventricular tachycardia after surgical repair of tetralogy of Fallot: results of intraoperative mapping studies.
MedLine Citation:
PMID:  1512345     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Four patients with previous repair of tetralogy of Fallot and ventricular tachycardia underwent map-guided surgery to ablate the arrhythmias. BACKGROUND: Although patients with repaired tetralogy of Fallot are at increased risk of sudden death due to ventricular tachycardia, little is known of the origin and mechanism of this arrhythmia. METHODS: A customized right ventricular balloon with 112 electrodes was used to record endocardial activation and, where possible, simultaneous epicardial recordings were obtained with a sock electrode array. Three patients had an aneurysm of the right ventricular outflow tract and one had a septal aneurysm. All had moderate to severe pulmonary valve insufficiency. Preoperative electrophysiologic study demonstrated inducible rapid (cycle length 180 to 300 ms) hemodynamically unstable monoform ventricular tachycardias. RESULTS: Intraoperatively, five different tachycardias (two in one patient) were induced and mapped. The sites of earliest activation were located in the subendocardium of the right ventricular outflow tract in all, but they varied widely among the septum, free wall and parietal band and could not be identified by visible scar. All were due to a macroreentrant circuit initiated by a critical delay in activation beyond a functional arc of block. Two patients treated by cryoablation while the heart was beating and perfused at normal temperature had inducible ventricular tachycardia postoperatively. In the two subsequent patients, the application of cryoablation under anoxic cardiac arrest resulted in noninducibility of arrhythmia. CONCLUSIONS: Ventricular tachycardia in tetralogy of Fallot in these four patients was caused by macroreentry in the right ventricular outflow tract. Surgical success depends on detailed mapping and cryoablation under anoxic cardiac arrest. In patients at risk of sudden death, map-directed surgery may offer distinct advantages over either implantable devices or drug therapy.
E Downar; L Harris; S Kimber; L Mickleborough; W Williams; E Sevaptsidis; S Masse; T C Chen; A Chan; A Genga
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  20     ISSN:  0735-1097     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1992-09-30     Completed Date:  1992-09-30     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  648-55     Citation Subset:  AIM; IM    
Division of Cardiology, Toronto General Hospital, Ontario, Canada.
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MeSH Terms
Child, Preschool
Cryosurgery / methods*
Electrocardiography / methods*
Heart Ventricles
Monitoring, Intraoperative*
Signal Processing, Computer-Assisted
Tachycardia / etiology,  physiopathology,  surgery*
Tetralogy of Fallot / complications*,  surgery

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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