Document Detail

Ventricular restraint therapy for heart failure: A review, summary of state of the art, and future directions.
MedLine Citation:
PMID:  22749626     Owner:  NLM     Status:  Publisher    
Congestive heart failure is a leading cause of death in developed countries, and its incidence is expected to increase in parallel with the aging population. Most current therapies for congestive heart failure lead to modest symptom relief but are unable to significantly improve long-term survival outcomes. Indeed, there is no effective treatment except cardiac transplantation, which remains epidemiologically insignificant because of donor pool limitations. New strategies for treating congestive heart failure are needed. Ventricular restraint is a promising, nontransplant surgical therapy in which the overall goal is to wrap the dilated, failing heart with prosthetic material to mechanically constrain the heart at end-diastole, prevent further remodeling, and thereby ultimately improve ventricular function, patient symptoms, and survival. In this review, the principles of cardiac restraint therapy will be discussed. An overview of 3 restraint devices, along with their specific advantages and disadvantages, will be presented. The existing peer-reviewed literature from both animal and human trials will be summarized with an emphasis on understanding the mechanism of restraint therapy and how this knowledge can be used to optimize and improve its efficacy.
Michael H Kwon; Marisa Cevasco; Jan D Schmitto; Frederick Y Chen
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Publication Detail:
Type:  EDITORIAL     Date:  2012-6-30
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  -     ISSN:  1097-685X     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-7-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.
Division of Cardiac Surgery, Department of Surgery, Brigham and Woman's Hospital, Harvard Medical School, Boston, Mass.
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