Document Detail

Ventricular repolarization pattern under heart cooling in the rabbit.
MedLine Citation:
PMID:  18284376     Owner:  NLM     Status:  MEDLINE    
AIM: Prolongation of ventricular repolarization is characteristic of myocardial cooling. In the present study, we investigated whether this prolongation is uniform or not throughout ventricular epicardium and how these hypothermia-induced changes express in the body surface potential distribution. METHODS: Epicardial and body surface potential mapping from 64 unipolar leads was carried out in 18 anaesthetized adult rabbits. Mild hypothermia documented by lowering the mediastinal and rectal temperature from 38 to 32 degrees C was elicited by perfusion of the mediastinum with cooled saline. Activation times, repolarization times and activation-recovery intervals were determined in each epicardial lead. RESULTS: Baseline activation-recovery intervals distributed non-uniformly on the ventricular epicardium, increasing progressively from the apex to the base and from the left ventricular (LV) sites to the right ventricular (RV) sites (P < 0.05), governing the repolarization sequence of ventricular epicardium. Heart cooling from 38 to 32 degrees C produced the heterogeneous prolongation of activation-recovery intervals which was more pronounced at the apex than at the base, and in the LV areas compared to the RV areas (P < 0.05). These nonuniform changes in local repolarization durations resulted in the development of base-to-apex repolarization sequence and inversion of the body surface potential distribution during the T wave. CONCLUSION: Thus, under cooling the rabbit heart from 38 to 32 degrees C, the nonuniform prolongation of local repolarization durations resulted in the reversal of ventricular epicardial repolarization sequence which, in turn, was responsible for the inversion in the body surface potential distribution during the T wave.
J E Azarov; D N Shmakov; V A Vityazev; I M Roshchevskaya; N V Arteyeva; S N Kharin; M P Roshchevsky
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-02-18
Journal Detail:
Title:  Acta physiologica (Oxford, England)     Volume:  193     ISSN:  1748-1716     ISO Abbreviation:  Acta Physiol (Oxf)     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-07     Completed Date:  2008-12-04     Revised Date:  2009-02-03    
Medline Journal Info:
Nlm Unique ID:  101262545     Medline TA:  Acta Physiol (Oxf)     Country:  England    
Other Details:
Languages:  eng     Pagination:  129-38     Citation Subset:  IM    
Laboratory of Cardiac Physiology, Institute of Physiology, Komi Science Center, Ural Division, Russian Academy of Sciences, Syktyvkar, Russia.
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MeSH Terms
Body Surface Potential Mapping / methods
Electrocardiography / methods
Heart Conduction System / physiology*
Heart Rate / physiology
Hypothermia, Induced*
Pericardium / physiology
Ventricular Function

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