Document Detail


Ventricular remodeling and infarct expansion.
MedLine Citation:
PMID:  8279368     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Infarct expansion, defined as an alteration in the ventricular topography due to thinning and lengthening of the infarcted segment, develops within the first few hours of the acute symptoms, mostly in patients with a large, transmural, anterior myocardial infarction. Shape changes, peculiar to risk region location and due to disparity in regional ventricular architecture, could be posited as the first step in the process of infarct expansion, with various cellular mechanisms contributing to subsequent continued early and late ventricular dilation. Because the increase in left ventricular volume is expected to be linearly dependent on the extent of the infarction, limiting infarct size, by thrombolysis, would proportionally reduce enlargement of the cavity. The effect of thrombolysis on left ventricular volume, however, seems not to be completely accounted for by the lessening effect of reperfusion on infarct size, because data suggest a restraining effect of reperfusion on the process of ventricular dilation in addition to the lessening effect on infarct size. If this turns out to be true, then the achievement of a patent vessel even beyond the time period when that patency may be expected to salvage myocardium would be further justified. Theoretical predictions substantiate the potential effectiveness in restraining ventricular dilation of stiffening of the necrotic region alone, independently of myocardial salvage in infarcted patients. The process of progressive ventricular dilation involves not only a primary alteration in function of the infarcted region, but also a time-dependent secondary change in the noninfarcted tissue itself, finalized to restore stroke volume despite a persistently depressed ejection fraction.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
P Zardini; P Marino; G Golia; M Anselmi; M Castelli
Related Documents :
8990648 - Audit of a rural hospital's coronary care unit: comparison of two predictive instrument...
8245328 - Thrombolytic therapy for women with myocardial infarction: is there a gender gap? throm...
16253588 - Relation of terminal qrs distortion to left ventricular functional recovery and remodel...
7594068 - Adverse long-term effects of reocclusion after coronary thrombolysis.
20176208 - Apical myectomy: a new surgical technique for management of severely symptomatic patien...
24722278 - Acupuncture promotes angiogenesis after myocardial ischemia through h3k9 acetylation re...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of cardiology     Volume:  72     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-02-04     Completed Date:  1994-02-04     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  98G-106G     Citation Subset:  AIM; IM    
Affiliation:
Division of Cardiology, University of Verona, Ospedale Maggiore, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Echocardiography
Heart Ventricles / pathology*
Humans
Myocardial Infarction / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Left ventricular function after coronary artery reperfusion.
Next Document:  Prognostic value of left ventricular mass in uncomplicated acute myocardial infarction and one-vesse...