| Ventricular remodeling in heart failure: the role of myocardial collagen. | |
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MedLine Citation:
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PMID: 8540401 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Collagen which is present in the myocardium in relatively small amounts is the most abundant structural protein of the connective tissue network. Its structural organization consists of a complex weave of collagen fibers that surrounds and interconnects myocytes, groups of myocytes, muscle fibers and muscle bundles. The conformation of interstitial fibrillar collagen makes it highly resistant to degradation by all proteinases other than specific collagenases. In hearts with myocardial damage secondary to myocardial infarction, chronic ischemia, inflammation, or cardiomyopathy, a complex sequence of compensatory events occur that eventually result in an adverse left ventricular remodeling. This continual state of remodeling is characterized by persistent collagenase activity, fibrillar collagen degradation, and progressive myocyte loss. The net effect is a shift in the balance between collagen synthesis and degradation which leads to an inadequate fibrillar collagen matrix, progressive ventricular dilatation and sphericalization with wall thinning and eventual congestive heart failure. |
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Authors:
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J S Janicki; G L Brower; J R Henegar; L Wang |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Advances in experimental medicine and biology Volume: 382 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 1995 |
Date Detail:
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Created Date: 1996-02-02 Completed Date: 1996-02-02 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 239-45 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Dalton Cardiovascular Research Center, University of Missouri, Columbia 65212, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Collagen
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metabolism* Heart Ventricles / metabolism*, pathology Myocardium / pathology* |
| Grant Support | |
ID/Acronym/Agency:
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R01-HL-46461/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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