Document Detail

Ventricular remodeling and function: insights using murine echocardiography.
MedLine Citation:
PMID:  19615377     Owner:  NLM     Status:  MEDLINE    
Extracellular matrix disturbances play an important role in the development of ventricular remodeling and failure. Genetically modified mice with abnormalities in the synthesis and degradation of extracellular matrix have been generated, in particular mice with deletion or overexpression of matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs). Echocardiography is ideally suited to serially evaluate left ventricular (LV) size and function, thus defining the progression of LV remodeling and failure. This Review describes the echocardiographic parameters that may provide insights into the development of ventricular remodeling and heart failure. The application of echocardiography to study LV remodeling and function after myocardial infarction and LV pressure-overload in wild-type mice and mice deficient or overexpressing MMPs or TIMPs is then detailed. Finally, using the example of mice deficient in nitric oxide synthase 3, a cautionary example is given illustrating discrepancies between the cardiac echocardiographic phenotype and modifications of the extracellular matrix.
Marielle Scherrer-Crosbie; Baptiste Kurtz
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-07-15
Journal Detail:
Title:  Journal of molecular and cellular cardiology     Volume:  48     ISSN:  1095-8584     ISO Abbreviation:  J. Mol. Cell. Cardiol.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-17     Completed Date:  2010-05-14     Revised Date:  2012-10-09    
Medline Journal Info:
Nlm Unique ID:  0262322     Medline TA:  J Mol Cell Cardiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  512-7     Citation Subset:  IM    
Copyright Information:
2009 Elsevier Ltd. All rights reserved.
Cardiac Ultrasound Laboratory, Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
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MeSH Terms
Echocardiography / methods*
Heart Failure / genetics,  physiopathology
Matrix Metalloproteinases / genetics,  metabolism
Nitric Oxide / metabolism
Tissue Inhibitor of Metalloproteinases / genetics,  metabolism
Ventricular Remodeling / genetics,  physiology*
Grant Support
S10 RR022586/RR/NCRR NIH HHS; S10 RR022586-01A1/RR/NCRR NIH HHS
Reg. No./Substance:
0/Tissue Inhibitor of Metalloproteinases; 10102-43-9/Nitric Oxide; EC 3.4.24.-/Matrix Metalloproteinases

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