Document Detail

Ventricular remodeling after myocardial infarction and effects of ACE inhibition on hemodynamics and scar formation in SHR.
MedLine Citation:
PMID:  11934599     Owner:  NLM     Status:  MEDLINE    
The effect of ACE inhibition after myocardial infarction (MI) on MI healing and remodeling in the presence of hypertension is not exactly known. Therefore, the effect of quinapril on scar formation, remodeling and hemodynamics was studied in spontaneously hypertensive rats (SHR). Nine weeks after moderate and large MI, left ventricular end-diastolic pressure (LVEDP) and passive pressure-volume relations were similar in 28-week-old hypertensive and normotensive rats. Chronic therapy with quinapril (6 mg/kg/day, started 30 min post-MI) reduced LVEDP and LV to body weight ratio, yet did not affect pressure-volume relations. Quinapril increased MI size and reduced the content and brightness of collagen fibers in the scar examined by polarized light microscopy. In conclusion, ventricular dilatation after MI was not accelerated in SHR, probably due to LV hypertrophy. Quinapril produced beneficial hemodynamic effects similar to that observed in the normotensive rat model. The significance and timing of ACE inhibitor-induced impairment of scar formation need further evaluation.
Tomasz Zdrojewski; Peter Gaudron; Peter Whittaker; Sulamith Poelzl; Jürgen Schiemann; Kai Hu; Georg Ertl
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology     Volume:  11     ISSN:  1054-8807     ISO Abbreviation:  Cardiovasc. Pathol.     Publication Date:    2002 Mar-Apr
Date Detail:
Created Date:  2002-04-05     Completed Date:  2002-07-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9212060     Medline TA:  Cardiovasc Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  88-93     Citation Subset:  IM    
Medizinische Universitätsklinik, Universität Würzburg, Josef-Schneider Strasse 2, Würzburg 97080, Germany.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / pharmacology*,  therapeutic use
Cicatrix / drug therapy,  metabolism,  pathology
Collagen / drug effects,  metabolism
Disease Models, Animal
Hemodynamics / drug effects,  physiology
Hypertension / drug therapy,  enzymology,  physiopathology*
Isoquinolines / pharmacology*,  therapeutic use
Myocardial Infarction / drug therapy,  enzymology,  physiopathology*
Rats, Inbred SHR
Rats, Inbred WKY
Ventricular Dysfunction, Left / drug therapy,  enzymology,  physiopathology
Ventricular Remodeling / physiology*
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Isoquinolines; 0/Tetrahydroisoquinolines; 82586-55-8/quinapril; 9007-34-5/Collagen

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