Document Detail

Ventricular refractoriness during acute myocardial ischaemia and its relationship to ventricular fibrillation.
MedLine Citation:
PMID:  657178     Owner:  NLM     Status:  MEDLINE    
Studies were made in anaesthetised dog of the effects of repeated acute occlusions of a branch of the anterior descending coronary artery on ventricular refractory periods in adjacent ischaemic and non-ischaemic myocardium. Differences occurred in refractoriness between normal and ischaemic areas in the ventricle. This was greatest 2.5 min after occlusion, and on release of occlusion, ventricular refractory periods reverted to normal within 5 min. Spontaneous ventricular fibrillation was directly and significantly related to the degree of dispersion of refractoriness in a given dog immediately preceding release and following release of occlusion. Infusion of isoprenaline caused significant shortening of refactory period and increased dispersion of refractoriness during ischaemia. Studies of dispersion of refractoriness should prove valuable in assessing the efficiency of metabolic or antiarrhythmic protection against ventricular fibrillation.
D C Russell; M F Oliver
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiovascular research     Volume:  12     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1978 Apr 
Date Detail:
Created Date:  1978-09-01     Completed Date:  1978-09-01     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  221-7     Citation Subset:  IM    
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MeSH Terms
Coronary Disease / complications,  physiopathology*
Heart Ventricles / drug effects,  physiopathology*
Isoproterenol / pharmacology
Ventricular Fibrillation / etiology*
Reg. No./Substance:

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