| Ventricular noradrenaline concentrations in naïve and morphine-treated rats subjected to acute myocardial ischaemia. | |
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MedLine Citation:
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PMID: 3390648 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1 Ventricular noradrenaline concentrations in morphine-treated rats subjected to acute left coronary artery ligation were measured by high performance liquid chromatography with electrochemical detection. 2 In naïve rats, acute left coronary artery ligation induced a significant increase in right ventricular noradrenaline concentration at 5 min and significant decreases in left ventricular noradrenaline concentration at 3 and 10 min. 3 Acute morphine treatment did not significantly alter ventricular noradrenaline concentrations in rats subjected to acute coronary artery ligation. 4 Chronic morphine treatment caused significant declines in ventricular noradrenaline concentrations in rats subjected to acute coronary artery ligation. The reductions increased with duration of opiate treatment, and were reversed by opiate withdrawal. 5 These findings indicate that there is an increase in sympathetic activity during acute myocardial ischaemia. It is suggested that chronic morphine treatment may be able to retard this response, and consequently to lessen the occurrence of early ventricular arrhythmias resulting from acute myocardial ischaemia. |
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Authors:
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W W Ko; S Dai; M Y Chan |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of pharmacology Volume: 93 ISSN: 0007-1188 ISO Abbreviation: Br. J. Pharmacol. Publication Date: 1988 Apr |
Date Detail:
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Created Date: 1988-08-18 Completed Date: 1988-08-18 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 723-8 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Faculty of Medicine, University of Hong Kong. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Disease / metabolism* Coronary Vessels / physiology Male Morphine / pharmacology* Myocardium / metabolism* Norepinephrine / metabolism* Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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51-41-2/Norepinephrine; 57-27-2/Morphine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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