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Ventricular non-compaction cardiomyopathy: prenatal diagnosis and pathology.
MedLine Citation:
PMID:  25346355     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the prenatal diagnosis of ventricular non-compaction cardiomyopathy (NCCM) and to report the pathologic features and the characteristic myocardial ultrastructure of fetal NCCM.
METHOD: We examined 9 cases of fetal NCCM by prenatal echocardiography from 2004 to 2013. These cases were evaluated with respect to prenatal diagnosis, outcomes, pathology and characteristics of the myocardial ultrastructure.
RESULTS: Trabeculated myocardium and non-compaction/compaction ratio (N/C ratio) ≥2.0 is the echocardiographic feature that allowed diagnosis. Among the 9 fetuses with a prenatal diagnosis of NCCM, 6 were diagnosed with left ventricular non-compaction (LVNC), 2 with non-compaction of both ventricles (biventricular NCCM), and 1 with right ventricular non-compaction (RVNC). Among the 9 fetuses, the LVNC diagnosis was confirmed by postnatal echocardiography in 2; the other patients chose to terminate their pregnancies, and those cases were confirmed at autopsy. Muscle biopsies were performed on 3 of the aborted fetuses, and abnormal mitochondria, sarcomeres and myocardial fibers were observed.
CONCLUSION: Non-compaction can be identified in the fetus. Fetal non-compaction most often involves the LV, but can involve the RV or both ventricles. The myocardial ultrastructure of fetal ventricular non-compaction has certain unique characteristics regarding the maturation of the mitochondria, sarcomeres and myocardial fibers. This article is protected by copyright. All rights reserved.
Authors:
Leiqi Tian; Qichang Zhou; Jia Zhou; Shi Zeng; Danming Cao; Ming Zhang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-10-24
Journal Detail:
Title:  Prenatal diagnosis     Volume:  -     ISSN:  1097-0223     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-10-27     Completed Date:  -     Revised Date:  2014-10-28    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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