Document Detail

Ventricular late potentials in systemic sclerosis: relationship with skin involvement.
MedLine Citation:
PMID:  12136893     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To detect the myocardial involvement in patients with systemic sclerosis (SSc) by signal averaged electrocardiography method (SA-ECG) in relationship to the skin changes. METHODS: We selected 24 SSc outpatients according to American Rheumatism Association criteria, without clinical and instrumental evidence of cardiac disease, and compared them with 24 control subjects. All patients and controls underwent SA-ECG to detect ventricular late potentials (LP). The extent and severity of skin involvement in SSc patients was detected by modified Rodnan (m-Rodnan) skin score. RESULTS: SSc patients had higher prevalence of LP compared to controls (46 versus 8%, p < 0.003). Median skin score value in the overall SSc population was 7 [mean, SD (range): 7.8, 3.2, (4-18)]. Patients with LP had a higher median skin score value compared to SSc patients without LP [median (range): 10 (6-18) versus 6 (4-9); Mann-Whitney U test 22.5, p < 0.005]. A subset analysis was also performed to verify the correlation of antibodies positivity (anti-centromere and Scl 70) pattern and the presence of LP. Our findings showed that higher values of skin score correlated with the presence of LP independent of antibody subsets. CONCLUSIONS: Our data suggest that diffuse abnormalities of the cardiac tissue detected by SA-ECG may be present, even in patients without cardiac symptoms. The relationship between LP and skin involvement in patients without clinical evidence of cardiac involvement may help detect of a subset of patients who may develop scleroderma heart disease.
Michele Paradiso; Manuela Di Franco; Antonino Musca; Stefania Basili; Valeria Riccieri; Vincenzo Paoletti; Antonio De Matteis; Antonio Mammarella
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  29     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-24     Completed Date:  2003-01-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  1388-92     Citation Subset:  IM    
Department of Medical Therapy, University La Sapienza, Rome, Italy.
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MeSH Terms
Cardiomyopathies / diagnosis*,  etiology
Case-Control Studies
Electrocardiography / methods*
Middle Aged
Reference Values
Sampling Studies
Scleroderma, Localized / complications,  diagnosis
Scleroderma, Systemic / complications*,  diagnosis
Sensitivity and Specificity
Severity of Illness Index
Signal Processing, Computer-Assisted*
Statistics, Nonparametric
Ventricular Function

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