| Ventricular hypertrophy and cavity dilatation in relation to body mass index in women with uncomplicated obesity. | |
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MedLine Citation:
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PMID: 20483890 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: The traditionally accepted mechanism for ventricular adaptation to obesity suggests that cavity dilatation in response to increased blood volume and elevated filling pressure results in ventricular hypertrophy as a compensatory mechanism. Our hypothesis was that, instead, initiation of ventricular hypertrophy in obesity may be explained by changes in hormonal milieu and not by cavity dilatation. RESEARCH DESIGN AND METHODS: 88 female subjects without identifiable cardiovascular risk factors, covering a wide range of body mass indices (BMI), from normal (21.2 ± 1.6 kg/m(2)) to severely obese (45.0 ± 4.6 kg/m(2)), underwent cardiovascular MRI to determine left ventricular (LV) and right ventricular (RV) mass and volumes. RESULTS: BMI correlated positively with LV and RV mass and end-diastolic volumes (EDV). However overweight is associated with a significant LV and RV hypertrophy (LV: 78 ± 11 g vs 103 ± 16 g, p<0.01; RV: 26 ± 7 g vs 40 ± 11 g, p<0.01) was observed in the absence of differences in LV and RV volumes (LV: EDV 119 ± 15 vs 121 ± 21 ml, p>0.99, RV: 131 ± 17 vs 130 ± 24 ml; p>0.99). Furthermore, significant increases of serum leptin occurred at this pre-obese stage (15.6 ± 19 vs 36.5 ± 22 ng/ml; p=0.013). CONCLUSION: In a cohort of healthy female subjects with a wide range of BMIs, ventricular hypertrophy occurs without associated cavity dilatation in overweight individuals, while in manifest obesity, both cavity dilatation and ventricular hypertrophy occur. Elevated leptin levels may have a role in this effect on ventricular mass. |
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Authors:
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Oliver J Rider; Steffen E Petersen; Jane M Francis; Mohammed K Ali; Lucy E Hudsmith; Monique R Robinson; Kieran Clarke; Stefan Neubauer |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-18 |
Journal Detail:
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Title: Heart (British Cardiac Society) Volume: 97 ISSN: 1468-201X ISO Abbreviation: Heart Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2010-12-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9602087 Medline TA: Heart Country: England |
Other Details:
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Languages: eng Pagination: 203-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiovascular Medicine, University of Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK. |
Export Citation:
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Descriptor/Qualifier:
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ID/Acronym/Agency:
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//British Heart Foundation; //Wellcome Trust |
| Comments/Corrections | |
Comment In:
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Heart. 2011 Feb;97(3):171-2
[PMID:
21189309
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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