Document Detail

Ventricular hypertrophy and cavity dilatation in relation to body mass index in women with uncomplicated obesity.
MedLine Citation:
PMID:  20483890     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The traditionally accepted mechanism for ventricular adaptation to obesity suggests that cavity dilatation in response to increased blood volume and elevated filling pressure results in ventricular hypertrophy as a compensatory mechanism. Our hypothesis was that, instead, initiation of ventricular hypertrophy in obesity may be explained by changes in hormonal milieu and not by cavity dilatation.
RESEARCH DESIGN AND METHODS: 88 female subjects without identifiable cardiovascular risk factors, covering a wide range of body mass indices (BMI), from normal (21.2 ± 1.6 kg/m(2)) to severely obese (45.0 ± 4.6 kg/m(2)), underwent cardiovascular MRI to determine left ventricular (LV) and right ventricular (RV) mass and volumes.
RESULTS: BMI correlated positively with LV and RV mass and end-diastolic volumes (EDV). However overweight is associated with a significant LV and RV hypertrophy (LV: 78 ± 11 g vs 103 ± 16 g, p<0.01; RV: 26 ± 7 g vs 40 ± 11 g, p<0.01) was observed in the absence of differences in LV and RV volumes (LV: EDV 119 ± 15 vs 121 ± 21 ml, p>0.99, RV: 131 ± 17 vs 130 ± 24 ml; p>0.99). Furthermore, significant increases of serum leptin occurred at this pre-obese stage (15.6 ± 19 vs 36.5 ± 22 ng/ml; p=0.013).
CONCLUSION: In a cohort of healthy female subjects with a wide range of BMIs, ventricular hypertrophy occurs without associated cavity dilatation in overweight individuals, while in manifest obesity, both cavity dilatation and ventricular hypertrophy occur. Elevated leptin levels may have a role in this effect on ventricular mass.
Oliver J Rider; Steffen E Petersen; Jane M Francis; Mohammed K Ali; Lucy E Hudsmith; Monique R Robinson; Kieran Clarke; Stefan Neubauer
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-05-18
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  97     ISSN:  1468-201X     ISO Abbreviation:  Heart     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2010-12-29     Completed Date:  2011-02-04     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  England    
Other Details:
Languages:  eng     Pagination:  203-8     Citation Subset:  AIM; IM    
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MeSH Terms
Body Mass Index*
Cardiomegaly / blood,  etiology*,  pathology
Cohort Studies
Hypertrophy, Left Ventricular / blood,  etiology,  pathology
Hypertrophy, Right Ventricular / blood,  etiology,  pathology
Insulin / blood
Insulin Resistance / physiology
Leptin / blood
Magnetic Resonance Imaging
Middle Aged
Obesity / blood,  complications*,  physiopathology
Ventricular Function, Left / physiology
Ventricular Function, Right / physiology
Grant Support
PS/02/002/14893//British Heart Foundation; RG/07/004/22659//British Heart Foundation; //British Heart Foundation; //Wellcome Trust
Reg. No./Substance:
0/Insulin; 0/Leptin
Comment In:
Heart. 2011 Feb;97(3):171-2   [PMID:  21189309 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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