| Ventricular function and natriuretic peptides in sequentially combined models of hypertension. | |
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MedLine Citation:
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PMID: 20139323 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hemodynamic parameters and natriuretic peptide levels were evaluated in cardiac hypertrophy produced by sequentially applied renovascular (RV) and deoxycorticosterone acetate-salt (DS) models of hypertension. We studied hypertensive rats by RV or DS treatment at 2 and 4 wk, as well as by the combination of 2 wk of each treatment in an inverse sequence: RV 2 wk/DS 2 wk (RV2/DS2) and DS 2 wk/RV 2 wk (DS2/RV2). The in vivo cardiac function, interstitial fibrosis, and synthesis and secretion of types A (ANP) and B (BNP) natriuretic peptides were monitored in hypertensive models compared with their corresponding sham (Sh2, Sh4). There were no differences in relaxation parameters among RV or DS groups and combined treatments. Left ventricular +dP/dt(max) increased only in RV4 (P < 0.01 vs. Sh4), and this increase was abolished in RV2/DS2. Interstitial collagen concentration increased after 4 wk in both RV4 and RV2/DS2 groups. Although there were no changes in collagen concentration in either DS2 or DS4 groups, clipping after 2 wk of DS (DS2/RV2) remarkably stimulated interstitial fibrosis (P < 0.01 vs. DS2). Plasma BNP increased in RV treatment at 4 wk (P < 0.001 vs. Sh4), but not in DS. Interestingly, RV applied after the 2 wk of DS treatment induced a marked increase in BNP levels (P < 0.001 vs. Sh4). In this regard, plasma BNP appears to be a reliable indicator of pressure overload. Our results suggest that the second stimulus of mechanical overload in combined models of hypertension determines the evolution of hypertrophy and synthesis and secretion of ANP and BNP. |
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Authors:
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Susana Cavallero; Germ?n E Gonz?lez; Ignacio M Seropian; Carolina S Cerrudo; Federico Matorra; Celina Morales; Cecilia M Hertig; Ana M Puy?; Belisario E Fern?ndez; Ricardo J Gelpi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-02-05 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 298 ISSN: 1522-1539 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-22 Completed Date: 2010-04-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H1290-9 Citation Subset: IM |
Affiliation:
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Department of Pathophysiology, Institute of Pathophysiology and Clinical Biochemistry, University of Buenos Aires, Argentina. susanac@ffyb.uba.ar |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atrial Natriuretic Factor / metabolism Biomechanics Blood Pressure / physiology Collagen / metabolism Desoxycorticosterone / adverse effects, analogs & derivatives Disease Models, Animal Hypertension / chemically induced, metabolism*, physiopathology* Hypertension, Renovascular / metabolism*, physiopathology* Male Natriuretic Peptide, Brain / metabolism Natriuretic Peptides / metabolism* Rats Rats, Sprague-Dawley Ventricular Function, Left / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Natriuretic Peptides; 114471-18-0/Natriuretic Peptide, Brain; 56-47-3/desoxycortone acetate; 64-85-7/Desoxycorticosterone; 85637-73-6/Atrial Natriuretic Factor; 9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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