Document Detail

Ventricular function following acute carbon monoxide exposure.
MedLine Citation:
PMID:  1176416     Owner:  NLM     Status:  MEDLINE    
Cardiac output function curves were used to investigate the effects of carbon monoxide on the heart in the conscious dog. Each dog was briefly exposed to 1,500 ppm carbon monoxide through a permanent tracheostomy. Immediately upon attaining either 10%, 20%, or 30% HbCO a rapid infusion of Ringer's lactate was given to test cardiac capabilities. The combined effects of carbon monoxide and infusion produced significant increases in cardiac output, heart rate, mean left ventricular pressure, dP/dt and (dP/dt)/IP. Cardiac output was sufficient to prevent peripheral hypoxia at all HbCO levels; however, there was evidence of impending cardiac depression beginning at 20% HbCO.
S H Cramlet; H H Erickson; H A Gorman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of applied physiology     Volume:  39     ISSN:  0021-8987     ISO Abbreviation:  J Appl Physiol     Publication Date:  1975 Sep 
Date Detail:
Created Date:  1975-12-20     Completed Date:  1975-12-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0376576     Medline TA:  J Appl Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  482-6     Citation Subset:  IM    
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MeSH Terms
Blood Pressure
Carbon Monoxide Poisoning / physiopathology*
Cardiac Output
Heart / physiopathology*
Heart Rate
Heart Ventricles / physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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