Document Detail

Ventricular fibrillation during right coronary arteriography with ioxaglate, iohexol and iopamidol in dogs.
MedLine Citation:
PMID:  3372179     Owner:  NLM     Status:  MEDLINE    
Radiograph contrast media (CM) are known to produce myocardial disturbances during cardiac angiography. The most severe electrical disturbance is ventricular fibrillation (VF). Previous studies using prolonged right coronary exposures have demonstrated a higher incidence of VF with dilute low sodium CM than with dilute CM containing more physiologic levels of sodium. In this study the incidence of VF was examined for more conventional concentrations of iopamidol, iohexol and ioxaglate and for sodium supplemented iohexol. The incidence of VF was determined during 25-second injections of contrast media into the canine right coronary artery at a rate of 0.4 mL/sec. Injections of iohexol and iopamidol at concentrations of 160, 240 and 320 mgI/mL produced significantly more VF (P less than .005, Fisher Exact Test) than meglumine/sodium ioxaglate or iohexol supplemented with 20 mM sodium chloride. The time required to produce a 50% incidence of VF with iohexol and iopamidol was significantly related to sodium concentration (r = .92, P less than .01).
T W Morris
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Investigative radiology     Volume:  23     ISSN:  0020-9996     ISO Abbreviation:  Invest Radiol     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-06-24     Completed Date:  1988-06-24     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0045377     Medline TA:  Invest Radiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  205-8     Citation Subset:  IM    
Department of Radiology, University of Rochester Medical Center 14642.
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MeSH Terms
Coronary Angiography*
Iohexol / diagnostic use,  toxicity*
Iopamidol / diagnostic use,  toxicity*
Ioxaglic Acid / diagnostic use,  toxicity*
Ventricular Fibrillation / chemically induced*
Grant Support
Reg. No./Substance:
59017-64-0/Ioxaglic Acid; 62883-00-5/Iopamidol; 66108-95-0/Iohexol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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