Document Detail

Ventricular fibrillation. A complication and hazard of transcatheter obliteration of the renal artery with absolute ethanol in dogs.
MedLine Citation:
PMID:  2579929     Owner:  NLM     Status:  MEDLINE    
Selective renal artery embolization with absolute ethanol was performed without balloon occlusion in a series of 11 healthy mongrel dogs. Electrocardiogram, blood ethanol level, heart rate, and blood pressure of the aorta and pulmonary artery were monitored. Ventricular extrasystoles and/or ventricular fibrillation occurred in six of the 11 dogs, to which absolute ethanol in doses ranging from 0.09 to 0.40 ml/kg was administered. In three of these six animals, the electrocardiograms showed only ventricular extrasystoles after intra-arterial bolus injection of absolute ethanol at doses of less than 0.15 ml/kg and subsequent recovery to a normal sinus rhythm. Ventricular fibrillation subsequent to ventricular extrasystoles immediately after intra-arterial injection of absolute ethanol at doses of more than 0.18 ml/kg occurred in three. In five of eight dogs that survived after alcohol injection in this series, a severe hypertensive response was observed. Absolute ethanol has the potential hazard of causing ventricular arrhythmia. Thus, careful observations should be undertaken in clinical therapeutic application of this agent, particularly in the absence of balloon occlusion, absolute ethanol should never be used without monitoring the electrocardiogram.
S Kusano; A Ohta
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Investigative radiology     Volume:  20     ISSN:  0020-9996     ISO Abbreviation:  Invest Radiol     Publication Date:    1985 Jan-Feb
Date Detail:
Created Date:  1985-05-09     Completed Date:  1985-05-09     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0045377     Medline TA:  Invest Radiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  36-41     Citation Subset:  IM    
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MeSH Terms
Aorta / physiology
Blood Pressure
Cardiac Complexes, Premature / chemically induced*
Embolization, Therapeutic / adverse effects*
Ethanol / administration & dosage,  adverse effects*
Heart Rate
Pulmonary Artery / physiology
Renal Artery*
Time Factors
Ventricular Fibrillation / chemically induced*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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