Document Detail

Ventricular expression of atrial natriuretic peptide in chronic chagasic cardiomyopathy is not induced by myocarditis.
MedLine Citation:
PMID:  12659985     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The ventricles of the normal heart are virtually devoid of atrial natriuretic peptide (ANP). Although ANP occurs in ventricles submitted to elevated wall stress, it is not clear whether ANP expression is affected by myocarditis. We investigated the immunohistochemical expression of ANP in chronic chagasic cardiomyopathy, an inflammatory cardiomyopathy caused by infection with the protozoan Trypanosoma cruzi. METHODS: Necropsy samples from the left and right ventricles of 16 patients exhibiting chronic chagasic cardiomyopathy were evaluated for myocarditis, fibrosis, T. cruzi parasites and ANP immunoreactivity. The diameters of 50 myocytes per sample were measured. RESULTS: ANP was present in myocytes of the subendocardial region in 13/16 (81.3%) left and 10/16 (62.5%) right ventricular samples (P=0.25). Myocytes present in the inflammatory foci, near the infiltrating inflammatory cells but distant from the subendocardial region, did not express ANP. Trypanosoma cruzi parasites exhibited intense immunoreactivity for ANP. The mean myocyte diameter and the incidence of myocarditis, fibrosis, and T. cruzi parasites was similar between the left and right ventricular samples. No statistical differences were found between the ANP-positive and ANP-negative cases. CONCLUSIONS: In chronic chagasic cardiomyopathy, both ventricles exhibit hypertrophy, fibrosis and ANP in the subendocardial region. The inflammatory infiltrate does not induce ANP expression in the myocytes. Regional stress but not myocarditis itself, is probably responsible for ventricular ANP expression in myocarditis.
Luiz A Benvenuti; Vera D Aiello; Suely A P Palomino; Maria de L Higuchi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of cardiology     Volume:  88     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-27     Completed Date:  2003-06-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  57-61     Citation Subset:  IM    
Laboratory of Pathology, Heart Institute (InCor), University of Sao Paulo Medical School, Av. Dr. Eneas de Carvalho Aguiar 44, 05403-000, Sao Paulo, Brazil.
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MeSH Terms
Atrial Natriuretic Factor / analysis*,  immunology
Chagas Cardiomyopathy / complications,  immunology*,  pathology*
Chronic Disease
Fibrosis / etiology,  immunology,  pathology
Heart Ventricles / chemistry*,  immunology,  pathology*
Middle Aged
Muscle Fibers, Skeletal / chemistry,  immunology,  pathology
Myocarditis / etiology,  immunology*,  pathology*
Trypanosoma cruzi / isolation & purification
Reg. No./Substance:
85637-73-6/Atrial Natriuretic Factor

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