Document Detail


Ventricular dilatation in relation to outcome at 2 years of age in very preterm infants: a prospective Finnish cohort study.
MedLine Citation:
PMID:  21039438     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: The aim of this study was to analyse the relation between ventricular dilatation at term and neurodevelopmental outcome at 2 years corrected age in infants of very low birthweight (VLBW) or very low gestational age (VLGA).
METHOD: A total of 225 VLBW or VLGA infants (121 males, 104 female; mean birthweight 1133 g, SD 333 g; mean gestational age 29 wks, SD 2 wks 5d) born in Turku University Hospital were included. Ventricular-brain ratio and the widths of each lateral ventricular horn were determined using ultrasonography, and the volume of the ventricles was measured by magnetic resonance imaging at term. The 2-year outcome measures included scores for the Hammersmith Infant Neurological Examination, the presence of cerebral palsy (CP), the Mental Developmental Index (MDI) of the Bayley Scales of Infant Development (2nd edition), and the presence of severe hearing or vision impairments or any neurodevelopmental impairment (NDI).
RESULTS: CP was diagnosed in 15 participants (6.7%) and severe hearing deficit in 12 participants (5.3%). No severe vision impairment was found. Mild and severe cognitive delay was found in 24 (10.7%) and 8 (3.6%) of the VLBW or VLGA infants respectively. Isolated ventricular dilatation did not increase the risk for developmental impairments. However, ventricular dilatation with additional brain pathology was significantly associated with CP, MDI score below 70, and NDI. A ventricular-brain ratio above 0.35 was a sensitive measure of developmental impairment.
INTERPRETATION: Ventricular dilatation at term increases the risk of poor developmental outcome only when associated with other brain pathology. The ventricular-brain ratio is a useful clinical tool for determining the prognosis in VLBW and VLGA infants.
Authors:
Jonna Maunu; Liisa Lehtonen; Helena Lapinleimu; Jaakko Matomäki; Petriina Munck; Hellevi Rikalainen; Riitta Parkkola; Leena Haataja;
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Publication Detail:
Type:  Journal Article     Date:  2010-10-13
Journal Detail:
Title:  Developmental medicine and child neurology     Volume:  53     ISSN:  1469-8749     ISO Abbreviation:  Dev Med Child Neurol     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-03     Completed Date:  2011-01-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0006761     Medline TA:  Dev Med Child Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  48-54     Citation Subset:  IM    
Copyright Information:
© The Authors. Journal compilation © Mac Keith Press 2010.
Affiliation:
Department of Paediatric Neurology, University of Turku and Turku University Hospital, Turku, Finland. jonna.maunu@utu.fi
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MeSH Terms
Descriptor/Qualifier:
Cerebral Ventricles / abnormalities*,  pathology
Child, Preschool
Cohort Studies
Dilatation, Pathologic / pathology
Female
Finland / epidemiology
Gestational Age
Humans
Infant
Infant, Newborn
Magnetic Resonance Imaging / methods
Male
Outcome Assessment (Health Care) / methods
Premature Birth / epidemiology*,  pathology*,  physiopathology
Severity of Illness Index
Ultrasonography, Doppler / methods
Investigator
Investigator/Affiliation:
Mikael Ekblad / ; Satu Ekblad / ; Eeva Ekholm / ; Leena Haataja / ; Mira Huhtala / ; Pentti Kero / ; Riikka Korja / ; Harry Kujari / ; Helena Lapinleimu / ; Liisa Lehtonen / ; Marika Leppänen / ; Annika Lind / ; Hanna Manninen / ; Jaakko Matomäki / ; Jonna Maunu / ; Petriina Munck / ; Pekka Niemi / ; Pertti Palo / ; Riitta Parkkola / ; Jorma Piha / ; Liisi Rautava / ; Päivi Rautava / ; Milla Reiman / ; Hellevi Rikalainen / ; Katriina Saarinen / ; Elina Savonlahti / ; Matti Sillanpää / ; Suvi Stolt / ; Päivi Tuomikoski-Koiranen / ; Anniina Väliaho / ; Tuula Aärimaa /

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