| Ventricular diastolic function of ankylosing spondylitis patients by using conventional pulsed wave Doppler, myocardial performance index and tissue Doppler imaging. | |
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MedLine Citation:
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PMID: 18271873 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The aim of this study was to evaluate ventricular functions by using standard Doppler echocardiography (SDE), myocardial performance index (MPI), and pulsed wave tissue Doppler imaging (PW-TDI) in patients with ankylosing spondylitis (AS) and healthy controls. METHODS: Forty-nine AS patients (38 +/- 11 years, 25 M/24 F) and 33 controls (36 +/- 9 years, 17 M/16 F) were studied. Two-dimensional, M-Mode, SDE, PW-TDI echocardiography examinations were performed. Spinal mobility was assessed by the Bath ankylosing spondylitis metrology index (BASMI) measurement. Patients were also evaluated using the Bath ankylosing spondylitis functional index (BASFI) and the Bath ankylosing spondylitis disease activity index (BASDAI). RESULTS: Four control subjects and six AS patients met the left ventricular (LV) diastolic dysfunction (DD) criteria by using conventional Doppler echocardiography (p > 0.05). However, using PW-TDI method 22 patients in the AS group and six subjects in the control group were diagnosed to have LV DD (Em/Am < 1). Pseudonormalized pattern was present in 16 AS patients and two control subjects. Correlation analysis revealed significant moderate negative correlations between Em/Am and BASMI, age and body mass index (p < 0.05; r =-0.3, -0.6, and -0.4, respectively). No correlation was observed between Em/Am and disease duration, BASFI, BASDAI, CRP, and ESR. We could not detect any right ventricular function involvement either by conventional or by recently introduced echocardiography methods. The risk of developing LV DD was found to be 3.7 times higher in AS patients. CONCLUSION: When sensitive echocardiographic Doppler techniques such as MPI, TDI-derived MPI, and PW-TDI are utilized, DD can be detected in a significant proportion of patients with AS without cardiovascular (CV) disease which may contribute CV mortality in these patients. |
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Authors:
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Taha Okan; Ismail Sari; Servet Akar; Hasan Cece; Ozhan Goldeli; Sema Guneri; Nurullah Akkoc |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Echocardiography (Mount Kisco, N.Y.) Volume: 25 ISSN: 0742-2822 ISO Abbreviation: Echocardiography Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-02-14 Completed Date: 2008-05-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8511187 Medline TA: Echocardiography Country: United States |
Other Details:
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Languages: eng Pagination: 47-56 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Dokuz Eylul University School of Medicine, Izmir, Turkey. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Case-Control Studies Chi-Square Distribution Diastole / physiology Echocardiography, Doppler, Pulsed* Female Humans Logistic Models Male Middle Aged Questionnaires Spondylitis, Ankylosing / physiopathology*, ultrasonography* Ventricular Dysfunction, Left / physiopathology*, ultrasonography* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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