Document Detail


Ventricular cryosurgery: short-term effects on intramural electrophysiology.
MedLine Citation:
PMID:  6838265     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The acute effects of cryothermia on regional electrophysiology were examined in order to devise a means of localizing and monitoring the intramural progression of ventricular cryolesions during a two-minute period of cryothermia application. Intramural unipolar electrograms were recorded from multipoint plunge electrodes placed in the left ventricle in 15 dogs. Epicardial, intramural, and endocardial applications of cryothermia were then employed, and changes in the unipolar peak-to-peak amplitude (UPPA) of electrograms were recorded. The location and depth of the ultimate permanent cryolesion could be predicted by noting locations of those electrograms demonstrating a decrease in the UPPA to less than 30% of the control values. Such electrophysiological monitoring of the region of myocardium undergoing cryothermic ablation provides a means of limiting the ultimate cryolesion to the desired location and depth within the ventricular wall. This allows precise placement of cryolesions in specific areas of the left ventricle for the treatment of ventricular tachyarrhythmias by selectively ablating arrhythmogenic ventricular myocardium without inducing injury in surrounding nonarrhythmogenic myocardium.
Authors:
W L Holman; M Ikeshita; J M Douglas; P K Smith; G K Lofland; J L Cox
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  35     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  1983 Apr 
Date Detail:
Created Date:  1983-05-27     Completed Date:  1983-05-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  386-93     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cryosurgery*
Dogs
Electrodes, Implanted
Electrophysiology
Heart / physiopathology*
Heart Ventricles
Myocardial Contraction
Tachycardia / physiopathology,  surgery*
Grant Support
ID/Acronym/Agency:
HL06120/HL/NHLBI NIH HHS; HL06381/HL/NHLBI NIH HHS; HL25983/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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