Document Detail

Ventricular arrhythmias and mortality associated with isoflurane and sevoflurane in a porcine model of myocardial infarction.
MedLine Citation:
PMID:  21333167     Owner:  NLM     Status:  MEDLINE    
Ischemia of the myocardium can lead to reversible or irreversible injury depending on the severity and duration of the preceding ischemia. Here we compared sevoflurane and isoflurane with particular reference to their hemodynamic effects and ability to modify the effects of acute severe myocardial ischemia and reperfusion on ventricular arrhythmias and mortality in a porcine model of myocardial infarction. Female Large White pigs were premedicated with ketamine, midazolam, and atropine. Propofol was given intravenously for the anesthetic induction, and anesthesia was maintained with isoflurane or sevoflurane. Endovascular, fluoroscopy-guided, coronary procedures were performed to occlude the midleft anterior descending artery by using a coronary angioplasty balloon. After 75 min, the balloon catheter system was withdrawn and the presence of adequate reperfusion flow was verified. The pigs were followed for 2 mo, and overall mortality rate was calculated. The isoflurane group showed lower arterial pressure throughout the procedure, with the difference reaching statistical significance after induction of myocardial ischemia. The ventricular fibrillation rate was higher in isoflurane group (81.3%) than the sevoflurane group (51.7%; relative risk, 1.57 [1.03 to 2.4]). Overall survival was lower in the isoflurane group (75%) than the sevoflurane group (96.4%). In conclusion, in this porcine model of myocardial ischemia and reperfusion, sevoflurane was associated with higher hemodynamic stability and fewer ventricular arrhythmias and mortality than was isoflurane.
Marta Regueiro-Purriños; Felipe Fernández-Vázquez; Armando Perez de Prado; Jose R Altónaga; Carlos Cuellas-Ramón; Jose M Ajenjo-Silverio; Asuncion Orden; Jose M Gonzalo-Orden
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of the American Association for Laboratory Animal Science : JAALAS     Volume:  50     ISSN:  1559-6109     ISO Abbreviation:  J. Am. Assoc. Lab. Anim. Sci.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-02-21     Completed Date:  2011-08-15     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  101269489     Medline TA:  J Am Assoc Lab Anim Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  73-8     Citation Subset:  IM    
Fundación Investigación Sanitaria en León, and Institute of Biomedicine, University of León, León, Spain.
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MeSH Terms
Anesthetics, Inhalation / therapeutic use*
Animal Welfare
Arrhythmias, Cardiac / complications,  mortality,  prevention & control,  veterinary*
Disease Models, Animal
Isoflurane / therapeutic use*
Methyl Ethers / therapeutic use*
Myocardial Infarction / complications*
Myocardial Reperfusion Injury / complications,  mortality,  prevention & control,  veterinary*
Survival Rate
Swine Diseases / mortality,  prevention & control*
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Methyl Ethers; 26675-46-7/Isoflurane; 28523-86-6/sevoflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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