| Ventricular arrhythmia in dialysis patients: a link with higher hemoglobin levels? | |
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MedLine Citation:
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PMID: 21481156 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the frequencies and associated risk factors of cardiac arrhythmias and heart rate variability (HRV) in hemodialysis (HD) patients. One hundred fifty prevalent HD patients underwent 48-hour Holter monitoring. Holter monitoring was analyzed in 4 phases: early post-HD phase (12 hours), late post-HD phase (20 hours), pre-HD phase (12 hours), and HD phase (4 hours). Echocardiography was applied to measure the left ventricular mass index in a subgroup of patients (n: 52). Patients with ventricular premature contraction (VPC) were significantly older, had a longer HD duration, and higher hemoglobin (Hb) levels. Left ventricular mass index was significantly correlated with the frequency of VPC, during the HD and pre HD phases (r: 0.435, 0.312, respectively). In logistic regression analysis, patients with Hb level >11.9 g/dL (high tertile) had a 4.5-fold increased risk of VPC compared with those with Hb levels <10.8 g/dL (P: 0.04). In HRV analysis, age (P<0.001), and diabetes (P: 0.03) were found to be independent predictors of low standard deviation of all mean normal-to-normal RR intervals. Increased left ventricular mass index is associated with a high frequency of VPC in the pre-HD and HD periods. The occurrence of VPC is predicted by older age, longer dialysis duration, and higher Hb levels, while older age and diabetes are the determinants of HRV. The relation between higher Hb levels and the frequency of VPC might provide a clue for the explanation of the detrimental effect of higher Hb levels on HD patients. |
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Authors:
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Serkan Saygi; Gulay Asci; Hamad Dheir; Soner Duman; Meral Kayikcioglu; Mumtaz Yilmaz; Mehmet Ozkahya; Ercan Ok |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hemodialysis international. International Symposium on Home Hemodialysis Volume: 15 ISSN: 1542-4758 ISO Abbreviation: Hemodial Int Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-12 Completed Date: 2011-08-30 Revised Date: 2011-12-27 |
Medline Journal Info:
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Nlm Unique ID: 101093910 Medline TA: Hemodial Int Country: Canada |
Other Details:
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Languages: eng Pagination: 250-5 Citation Subset: IM |
Copyright Information:
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© 2011 The Authors. Hemodialysis International © 2011 International Society for Hemodialysis. |
Affiliation:
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Central Hospital, Department of Cardiology, Izmir, Turkey. serkankard@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arrhythmias, Cardiac
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blood*,
etiology*,
ultrasonography Echocardiography Electrocardiography, Ambulatory Female Hemoglobins / metabolism* Humans Male Middle Aged Renal Dialysis / adverse effects* Ventricular Premature Complexes / blood*, etiology*, ultrasonography |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins |
| Comments/Corrections | |
Comment In:
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Hemodial Int. 2011 Oct;15(4):581-2
[PMID:
22111830
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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