| Ventricular arrhythmia following short-acting nifedipine administration. | |
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MedLine Citation:
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PMID: 15880273 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Short-acting nifedipine is still advocated for use in children with severe hypertension, but is no longer recommended for use in adults because of adverse effects from rapid blood pressure reduction. A 19 year-old adolescent with symptomatic, severe hypertension (blood pressure 180/120) received 10 mg of short-acting nifedipine sublingually for blood pressure reduction. Within minutes after the dose, the patient complained of palpitations. Tachycardia (heart rate 100 beats per minute) and bigeminy were noted on the cardiac monitor. The bigeminy resolved but premature ventricular contractions were noted for the duration of her hospital stay. We hypothesize that reflex sympathetic activation following an abrupt drop in blood pressure may cause arrhythmias because of elevated catecholamine levels. Given this, it may be more appropriate to treat severe hypertension in children with intravenous antihypertensive agents that can be titrated to produce controlled reductions in blood pressure. |
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Authors:
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M Patricia Castaneda; Christine A Walsh; Robert P Woroniecki; Marcela Del Rio; Joseph T Flynn |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2005-05-07 |
Journal Detail:
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Title: Pediatric nephrology (Berlin, Germany) Volume: 20 ISSN: 0931-041X ISO Abbreviation: Pediatr. Nephrol. Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-06-16 Completed Date: 2005-10-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: Germany |
Other Details:
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Languages: eng Pagination: 1000-2 Citation Subset: IM |
Affiliation:
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Division of Pediatric Nephrology, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Sublingual Adult Female Humans Hypertension / drug therapy* Nifedipine / administration & dosage, adverse effects*, therapeutic use Tachycardia, Ventricular / chemically induced* Vasodilator Agents / administration & dosage, adverse effects*, therapeutic use Ventricular Premature Complexes / chemically induced* |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 21829-25-4/Nifedipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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