Document Detail

Ventricular arrhythmia, Cheyne-Stokes respiration, and death: observations from patients with defibrillators.
MedLine Citation:
PMID:  15814597     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether ventricular arrhythmia related to nocturnal hypoxaemia during Cheyne-Stokes respiration (CSR) explains the observation that CSR is an independent marker of death in heart failure.
DESIGN: Prospective, observational study.
PATIENTS: 101 patients at high risk of clinical serious ventricular arrhythmia fitted with an implantable cardioverter-defibrillator (ICD).
MEASUREMENTS: Patients were studied at baseline for CSR during sleep. Arrhythmia requiring device discharge was used as a surrogate marker for possible sudden cardiac death.
RESULTS: 101 patients (42 with CSR) were followed up for a total of 620 months. Twenty six patients experienced 432 ICD discharge episodes. Twenty four (6%), 210 (49%), 125 (29%), and 73 (17%) episodes occurred across the time quartiles 0000-0559, 0600-1159, 1200-1759, and 1800-2359, respectively. Kaplan-Meier analysis showed a relative risk of 1 (95% confidence interval 0.5 to 2.2, p = 1) for device discharge in the CSR group. The average (SED) numbers of nocturnal ICD discharges per patient per month of follow up were 0.01 (0.01) and 0.04 (0.02) for patients with and without CSR, respectively (p = 0.6).
CONCLUSION: These findings refute the proposition that CSR is related to heart failure death through nocturnal serious ventricular arrhythmia.
A D Staniforth; S C Sporton; M J Early; J A Wedzicha; A W Nathan; R J Schilling
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-04-06
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  91     ISSN:  1468-201X     ISO Abbreviation:  Heart     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-18     Completed Date:  2005-12-15     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  England    
Other Details:
Languages:  eng     Pagination:  1418-22     Citation Subset:  AIM; IM    
Department of Cardiovascular Medicine, Queens Medical Centre, Nottingham NG7 2UH, UK.
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MeSH Terms
Arrhythmias, Cardiac / blood,  etiology*,  therapy
Cheyne-Stokes Respiration / blood,  complications*
Death, Sudden, Cardiac / etiology*
Defibrillators, Implantable*
Disease-Free Survival
Heart Failure / blood,  complications*
Oximetry / methods
Oxygen / blood
Polysomnography / methods
Prospective Studies
Sleep Apnea, Obstructive / blood,  complications
Reg. No./Substance:

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