Document Detail


Ventricular function during exercise in mice and rats.
MedLine Citation:
PMID:  22012697     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mouse has many advantages over other experimental models for the molecular investigation of left ventricular (LV) function. Accordingly, there is a keen interest in, as well as an intense need for, a conscious, chronically instrumented, freely moving mouse model for the determination of cardiac function. To address this need, we used a telemetry device for repeated measurements of LV function in conscious mice at rest and during exercise. For reference, we compared the responses in mice to the responses in identically instrumented conscious rats. The transmitter body of the telemetry device (rat PA-C40; mouse PA-C10; Data Sciences International, St. Paul, MN) was placed in the intraperitoneal space through a ventral abdominal approach (rat) or subcutaneously on the left flank (mouse). The pressure sensor, located within the tip of a catheter, was inserted into the left ventricle through an apical stab wound (18 gauge for rat; 21 gauge for mouse) for continuous, nontethered, recordings of pulsatile LV pressure. A minimum of 1 wk was allowed for recovery and for the animals to regain their presurgical weight. During the recovery period, the animals were handled, weighed, and acclimatized to the laboratory, treadmill, and investigators. Subsequently, LV parameters were recorded at rest and during a graded exercise test. The results document, for the first time, serial assessment of ventricular function during exercise in conscious mice and rats. This methodology may be adopted for advancing the concepts and ideas that drive cardiovascular research.
Authors:
Heidi L Lujan; Hussein Janbaih; Han-Zhong Feng; Jian-Ping Jin; Stephen E DiCarlo
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2011-10-19
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  302     ISSN:  1522-1490     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-26     Completed Date:  2012-03-26     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R68-74     Citation Subset:  IM    
Affiliation:
Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.
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MeSH Terms
Descriptor/Qualifier:
Adjuvants, Anesthesia / pharmacology
Animals
Heart Rate / drug effects,  physiology
Male
Mice
Mice, Inbred C57BL
Models, Animal
Pentobarbital / pharmacology
Physical Conditioning, Animal / physiology*
Rats
Rats, Sprague-Dawley
Rest / physiology
Telemetry / instrumentation*,  methods*
Ventricular Function, Left / drug effects,  physiology*
Grant Support
ID/Acronym/Agency:
HL-88615/HL/NHLBI NIH HHS; HL-98945/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Adjuvants, Anesthesia; 76-74-4/Pentobarbital
Comments/Corrections

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