| Ventral tail bud mesenchyme is a signaling center for tail paraxial mesoderm induction. | |
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MedLine Citation:
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PMID: 14991715 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A large body of evidence from several systems indicates that formation of the vertebrate tail is morphogenetically continuous with gastrulation, including neural inducing activity in descendants of the gastrula organizer. However, the signaling centers and molecular events regulating tail mesoderm induction and its organized elongation remain poorly defined. In mammals, the ventral ectoderm ridge (VER) is essential to maintain ongoing formation of paraxial mesoderm and somitogenesis in cultures of intact tail. Avian tail buds contain a similar VER structure. Here, we report that the chick ventral tail bud operates as a signaling center for paraxial mesoderm induction. By using "organizer" style grafting assays to early host embryos, we found that ventral tail bud was able to induce elongated paraxial mesodermal extensions and that the ventral tail bud mesenchyme underlying the VER is both necessary and sufficient for the induction in this assay system. Our observations combined with those of others suggest that interplay between several different signaling centers in the amniote tail bud regulates the coordinate induction and elongation of axial and paraxial structures in the developing tail. |
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Authors:
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Chunqiao Liu; Vladimir Knezevic; Susan Mackem |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Developmental dynamics : an official publication of the American Association of Anatomists Volume: 229 ISSN: 1058-8388 ISO Abbreviation: Dev. Dyn. Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-03-01 Completed Date: 2004-10-06 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9201927 Medline TA: Dev Dyn Country: United States |
Other Details:
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Languages: eng Pagination: 600-6 Citation Subset: IM |
Affiliation:
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Laboratory of Pathology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland 20892, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Patterning Chick Embryo Coturnix Embryonic Induction Immunohistochemistry In Situ Hybridization Limb Buds / embryology* Mesoderm / metabolism* Signal Transduction Tail / embryology* |
| Grant Support | |
ID/Acronym/Agency:
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N01 HD-7-3263/HD/NICHD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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