| Ventral medullary surface responses to hypoxic and hyperoxic transient ventilatory challenges in the cat. | |
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MedLine Citation:
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PMID: 7603304 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Carotid body afferent contributions to activity of the intermediate area of the ventral medullary surface (IVMS) following transient hypoxia and hyperoxia were examined in 6 spontaneously breathing, pentobarbital-anesthetized cats. Two tidal breaths of 100% N2, 100% O2, or room air, were randomly administered before and after carotid sinus denervation (CSD). Images of scattered light from the IVMS showed that activity increased with hypoxia (10.1 +/- 2.4%), and decreased with hyperoxia (4.8 +/- 1.8%). CSD significantly increased the magnitude and delayed the onset of the hypoxic response, but reversed the initial component of the hyperoxic response. We conclude that carotid body afferents modulate the magnitude and timing of IVMS responses to transient respiratory challenges. |
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Authors:
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G Aljadeff; D Gozal; J L Carroll; D M Rector; R M Harper |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Life sciences Volume: 57 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1995 |
Date Detail:
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Created Date: 1995-08-10 Completed Date: 1995-08-10 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 319-24 Citation Subset: IM; S |
Affiliation:
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Dept. of Anat. & Cell Biol., UCLA Sch. of Med. 90095-1763, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anoxia / physiopathology* Carotid Body / physiology Cats Hyperoxia / physiopathology* Medulla Oblongata / physiology* Respiration* |
| Grant Support | |
ID/Acronym/Agency:
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HD-01072-02/HD/NICHD NIH HHS; HL-02543/HL/NHLBI NIH HHS; HL-22506/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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