Document Detail

Ventral medullary surface responses to hypoxic and hyperoxic transient ventilatory challenges in the cat.
MedLine Citation:
PMID:  7603304     Owner:  NLM     Status:  MEDLINE    
Carotid body afferent contributions to activity of the intermediate area of the ventral medullary surface (IVMS) following transient hypoxia and hyperoxia were examined in 6 spontaneously breathing, pentobarbital-anesthetized cats. Two tidal breaths of 100% N2, 100% O2, or room air, were randomly administered before and after carotid sinus denervation (CSD). Images of scattered light from the IVMS showed that activity increased with hypoxia (10.1 +/- 2.4%), and decreased with hyperoxia (4.8 +/- 1.8%). CSD significantly increased the magnitude and delayed the onset of the hypoxic response, but reversed the initial component of the hyperoxic response. We conclude that carotid body afferents modulate the magnitude and timing of IVMS responses to transient respiratory challenges.
G Aljadeff; D Gozal; J L Carroll; D M Rector; R M Harper
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Life sciences     Volume:  57     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1995  
Date Detail:
Created Date:  1995-08-10     Completed Date:  1995-08-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  319-24     Citation Subset:  IM; S    
Dept. of Anat. & Cell Biol., UCLA Sch. of Med. 90095-1763, USA.
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MeSH Terms
Anoxia / physiopathology*
Carotid Body / physiology
Hyperoxia / physiopathology*
Medulla Oblongata / physiology*
Grant Support

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