Document Detail

Ventral intermediate thalamic stimulation in complex tremor syndromes.
MedLine Citation:
PMID:  18334859     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: We report on deep brain stimulation (DBS) in the ventral intermediate part of the thalamus in 4 patients with complex tremor syndromes, 2 classified as Holmes tremor (HT) and 2 as thalamic tremor (TT). RESULTS: Three out of 4 patients showed intraoperative improvement and underwent DBS implantation. One patient with TT without intraoperative improvement was not provided with an implant. A sustained beneficial effect was present after a follow-up ranging from 20 months to 7 years, although there was partial persistence of the intentional tremor and of proximal myoclonic-dystonic movements. The mean global clinical impression score was 2. In 1 HT patient the benefit persisted after battery failure. CONCLUSION: The study confirms that ventral intermediate thalamic DBS can provide long-term efficacy for HT and TT. While the patients experienced considerable and lasting functional improvement, the effect was incomplete and not all elements of their complex movement disorders were equally suppressed.
N J Diederich; L Verhagen Metman; R A Bakay; F Alesch
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2008-03-12
Journal Detail:
Title:  Stereotactic and functional neurosurgery     Volume:  86     ISSN:  1423-0372     ISO Abbreviation:  Stereotact Funct Neurosurg     Publication Date:  2008  
Date Detail:
Created Date:  2008-05-14     Completed Date:  2008-10-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8902881     Medline TA:  Stereotact Funct Neurosurg     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  167-72     Citation Subset:  IM    
Copyright Information:
2008 S. Karger AG, Basel.
Department of Neurosciences, Centre Hospitalier de Luxembourg, Luxembourg-City, Luxembourg.
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MeSH Terms
Deep Brain Stimulation / methods*
Middle Aged
Tremor / pathology,  surgery*
Ventral Thalamic Nuclei / pathology,  surgery*

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