| Ventilatory and upper-airway resistance responses to upper-airway cooling and CO2 in anaesthetised rats. | |
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MedLine Citation:
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PMID: 7892113 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of upper airway (UA) cool air and CO2 on breathing and on laryngeal and supraglottic resistances were studied in anaesthetised rats breathing spontaneously through a tracheostomy. Warm, humidified air containing 0, 5 and 9-10% CO2 and cool, room-humidity air were delivered at constant flow to either the isolated larynx to exit through a pharyngotomy or to the supraglottic UA to exit through the mouth and/or nose (nose open or sealed). Spontaneous tracheal airflow and UA airflows, temperatures and pressures were recorded. CO2 had no effect on breathing but caused a slight increase in laryngeal resistance which was abolished by cutting the superior laryngeal nerves (SLN). Cool air caused a decrease in respiratory frequency and/or peak inspiratory flow when applied to the isolated larynx or to the supraglottic airway with the nose closed. These effects were abolished by SLN section. With the nose open, the ventilatory inhibition was not abolished by SLN section. Cool air also caused substantial decreases in laryngeal and supraglottic resistances which were attenuated by SLN section and which persisted following recurrent laryngeal nerve section. In conclusion, whilst UA cooling inhibits breathing and decreases UA resistances, UA CO2 has minimal effects. |
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Authors:
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K D O'Halloran; A K Curran; A Bradford |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pflügers Archiv : European journal of physiology Volume: 429 ISSN: 0031-6768 ISO Abbreviation: Pflugers Arch. Publication Date: 1994 Dec |
Date Detail:
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Created Date: 1995-04-20 Completed Date: 1995-04-20 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0154720 Medline TA: Pflugers Arch Country: GERMANY |
Other Details:
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Languages: eng Pagination: 262-6 Citation Subset: IM |
Affiliation:
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Department of Physiology, Royal College of Surgeons in Ireland, Dublin 2. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Airway Resistance* Animals Carbon Dioxide / metabolism* Cold Temperature* Larynx / physiology* Rats Rats, Wistar Respiratory Function Tests Temperature Trachea / physiology |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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