| Ventilatory support during exercise in patients with pulmonary tuberculosis sequelae. | |
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MedLine Citation:
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PMID: 9377909 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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STUDY OBJECTIVE: The aim of this study was to determine whether intermittent positive pressure ventilation through a nasal mask (NIPPV) applied during exercise in patients with pulmonary tuberculosis sequelae (PTS) could improve arterial blood gas measurements, ameliorate breathlessness, and increase exercise endurance. PATIENTS: Seven PTS patients with a severe restrictive ventilatory defect (mean [SD] vital capacity, 1.02 [0.25] I) enrolled in this study had experienced NIPPV previously, and were familiar with the procedure. DESIGN: The patients underwent four constant-load cycle ergometer tests in the supine position to tolerance. The tests were performed with and without NIPPV, while breathing normoxic air (Air) or supplemental oxygen (O2; 35%). NIPPV was delivered during exercise in a controlled, volume-cycled mechanical ventilation mode, and the ventilator settings were modulated manually to meet patients' respiratory demands as estimated from the airway pressure waveform and the patient's breathlessness. RESULTS: All patients matched their breathing to the ventilator cycle during most of the exercise while receiving NIPPV. NIPPV significantly prolonged their exercise endurance time, from a mean (SD) of 180 (58) s to 310 (96) s in Air, and from 227 (64) s to 465 (201) s in O2. During exercise, NIPPV effectively decreased their breathlessness and significantly improved arterial blood gas measurements. CONCLUSIONS: NIPPV applied during exercise can effectively support ventilation, significantly ameliorate breathlessness, and consequently improve exercise endurance in patients with PTS. |
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Authors:
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T Tsuboi; M Ohi; K Chin; H Hirata; N Otsuka; H Kita; K Kuno |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chest Volume: 112 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 1997 Oct |
Date Detail:
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Created Date: 1997-11-10 Completed Date: 1997-11-10 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1000-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Clinical Physiology, Chest Disease Research Institute, Kyoto University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Carbon Dioxide / blood Dyspnea / etiology, therapy Exercise Test Exercise Tolerance Female Forced Expiratory Volume / physiology Humans Intermittent Positive-Pressure Ventilation* / instrumentation, methods Male Masks Middle Aged Oxygen / blood Oxygen Inhalation Therapy Physical Endurance / physiology Physical Exertion / physiology* Pressure Pulmonary Ventilation / physiology Respiration / physiology Respiratory Insufficiency / etiology, physiopathology, therapy* Supine Position Total Lung Capacity / physiology Tuberculosis, Pulmonary / complications* Vital Capacity / physiology |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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