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Ventilatory strategies in septic patients : Results from a nationwide observational trial.
MedLine Citation:
PMID:  23319272     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Mortality in intensive care unit (ICU) patients is affected by multiple variables. The possible impact of the mode of ventilation has not yet been clarified; therefore, a secondary analysis of the "epidemiology of sepsis in Germany" study was performed. The aims were (1) to describe the ventilation strategies currently applied in clinical practice, (2) to analyze the association of the different modes of ventilation with mortality and (3) to investigate whether the ratio between arterial partial pressure of oxygen and inspired fraction of oxygen (PF ratio) and/or other respiratory variables are associated with mortality in septic patients needing ventilatory support. METHODS: A total of 454 ICUs in 310 randomly selected hospitals participated in this national prospective observational 1-day point prevalence of sepsis study including 415 patients with severe sepsis or septic shock according to the American College of Chest Physicians/Society of Critical Care Medicine criteria. RESULTS: Of the 415 patients, 331 required ventilatory support. Pressure controlled ventilation (PCV) was the most frequently used ventilatory mode (70.6 %) followed by assisted ventilation (AV 21.7 %) and volume controlled ventilation (VCV 7.7 %). Hospital mortality did not differ significantly among patients ventilated with PCV (57 %), VCV (71 %) or AV (51 %, p = 0.23). A PF ratio equal or less than 300 mmHg was found in 83.2 % of invasively ventilated patients (n = 316). In AV patients there was a clear trend to a higher PF ratio (204 ± 70 mmHg) than in controlled ventilated patients (PCV 179 ± 74 mmHg, VCV 175 ± 75 mmHg, p = 0.0551). Multiple regression analysis identified the tidal volume to pressure ratio (tidal volume divided by peak inspiratory airway pressure, odds ratio OR = 0.94, 95 % confidence interval 95% CI = 0.89-0.99), acute renal failure (OR = 2.15, 95% CI = 1.01-4.55) and acute physiology and chronic health evaluation (APACHE) II score (OR = 1.09, 95% CI = 1.03-1.15) but not the PF ratio (univariate analysis OR = 0.998, 95 % CI = 0.995-1.001) as independent risk factors for in-hospital mortality. CONCLUSIONS: This representative survey revealed that severe sepsis or septic shock was frequently associated with acute lung injury. Different ventilatory modes did not affect mortality. The tidal volume to inspiratory pressure ratio but not the PF ratio was independently associated with mortality.
Authors:
D Schädler; G Elke; C Engel; H Bogatsch; I Frerichs; R Kuhlen; R Rossaint; M Quintel; J Scholz; F M Brunkhorst; M Loeffler; K Reinhart; N Weiler;
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-16
Journal Detail:
Title:  Der Anaesthesist     Volume:  -     ISSN:  1432-055X     ISO Abbreviation:  Anaesthesist     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370525     Medline TA:  Anaesthesist     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Anesthesiology and Intensive Care Medicine, University Medical Center Schleswig-Holstein, Campus Kiel, Arnold-Heller-Str. 3, Haus 12, 24105, Kiel, Germany, dirk.schaedler@uksh.de.
Vernacular Title:
Beatmungsstrategien bei septischen Patienten : Ergebnisse einer nationalen Observationsstudie.
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