| Ventilatory responses to inhaled carbon dioxide, hypoxia, and exercise in idiopathic hyperventilation. | |
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MedLine Citation:
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PMID: 15059786 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Idiopathic hyperventilation (IH) is a poorly understood condition of sustained hypocapnia and controversial etiology. Although behavioral/emotional factors may contribute, it is uncertain whether chemosensitivity is altered, hyperventilation is maintained during exercise, and the associated breathlessness reflects the hyperventilation. In 39 patients with IH and 23 control subjects, we described ventilatory responses to isocapnic-hypoxia, hyperoxic-hypercapnia, and exercise; breath-hold tolerance; breathlessness; and psychologic status. Patients demonstrated hyperventilation at rest, with hypocapnia (28 +/- 3.8 mm Hg), a normal (slightly alkaline) arterial pH and [H(+)]a, and a significant base excess (-4.5 +/- 2.7 mEq/L), consistent with compensated respiratory alkalosis. Hyperventilation was sustained during exercise, despite hyperoxic-hypercapnic ventilatory responsiveness being normal and isocapnic-hypoxic ventilatory responsiveness being low relative to control (but exceeding control [2.4 +/- 1.0 vs. 1.6 +/- 0.5 L/min/%, p < 0.05] with acute restoration to normocapnia). Hyperventilation was maintained during exercise, at the resting CO(2) "setpoint." Relative to control, the breath-hold tolerance was attenuated, and dyspnea during exercise was significantly greater and not simply ascribable to the high ventilation. These observations suggest that patients with IH have a sustained hyperventilatory and dyspneic drive that, although not attributable to central chemosensitivity, may possibly have peripheral chemoreflex contributions. The nature and etiology of this chronic hyperventilatory drive remain unclear. |
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Authors:
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Sandy Jack; Harry B Rossiter; Michael G Pearson; Susan A Ward; Christopher J Warburton; Brian J Whipp |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2004-04-01 |
Journal Detail:
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Title: American journal of respiratory and critical care medicine Volume: 170 ISSN: 1073-449X ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2004-07-09 Completed Date: 2004-08-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 118-25 Citation Subset: AIM; IM |
Affiliation:
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Aintree Chest Centre, University Hospital Aintree, Liverpool L9 7AL, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Anoxia / complications, physiopathology* Carbon Dioxide / administration & dosage*, metabolism Chronic Disease Dyspnea / etiology, physiopathology Exercise / physiology* Female Humans Hypercapnia / complications, physiopathology Hyperventilation / complications, metabolism, physiopathology* Male Middle Aged Pulmonary Gas Exchange / physiology Pulmonary Ventilation / physiology* Reference Values Rest / physiology |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide |
| Comments/Corrections | |
Comment In:
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Am J Respir Crit Care Med. 2004 Jul 15;170(2):105-6
[PMID:
15242848
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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