Document Detail


Ventilatory responses to hypercapnia and hypoxia in Mash-1 heterozygous newborn and adult mice.
MedLine Citation:
PMID:  10541315     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Normal control of breathing is characterized by maintenance of CO2 and O2 arterial pressures at constant levels by appropriate ventilatory responses to changes in CO2 production and O2 consumption. Abnormal development of this regulatory system during embryogenesis may produce early impairments in chemosensitivity, as in congenital central hypoventilation syndrome. The present study addresses the role of the mammalian achaetescute homologous gene (Mash-1) in the development of respiratory control. We analyzed ventilatory responses to hypercapnia (8% CO2, 21% O2, 71% N2) and hypoxia (10% O2, 3% CO2, 87% N2) in newborn and adult Mash-1 heterozygous mice (Mash-1+/-) and their wild-type littermates (Mash-1+/+). Ventilation, breath duration, and tidal volume were measured using whole-body plethysmography. Ventilatory responses to hypercapnia were significantly weaker in newborn male Mash-1+/- compared with Mash-1+/+ mice as a result of a weaker breath-duration response. No differences were observed between adult Mash-1+/- and Mash-1+/+ mice. Our data suggest that Mash-1 may be involved in respiratory control development via mechanisms linked to the X chromosome.
Authors:
S Dauger; S Renolleau; G Vardon; V Népote; C Mas; M Simonneau; C Gaultier; J Gallego
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  46     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1999 Nov 
Date Detail:
Created Date:  1999-12-08     Completed Date:  1999-12-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  535-42     Citation Subset:  IM    
Affiliation:
Laboratoire de Neurologie et Physiologie du Développement, INSERM E9935, Hôpital Robert Debré, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Anoxia / physiopathology*
Basic Helix-Loop-Helix Transcription Factors
DNA-Binding Proteins / genetics*
Female
Heterozygote*
Male
Mice
Mice, Knockout
Respiratory System / growth & development,  physiopathology*
Transcription Factors / genetics*
Chemical
Reg. No./Substance:
0/Ascl1 protein, mouse; 0/Basic Helix-Loop-Helix Transcription Factors; 0/DNA-Binding Proteins; 0/Transcription Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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