Document Detail

Ventilatory responses to acute and chronic hypoxic hypercapnia in the ground squirrel.
MedLine Citation:
PMID:  7817046     Owner:  NLM     Status:  MEDLINE    
Golden-mantled ground squirrels exhibited a strong hypoxic ventilatory response but a blunted hypercapnic ventilatory response and showed no interactive effects when both stimuli were presented together. They exhibited a resting hypoxic ventilatory drive which was eliminated by carotid body denervation. Carotid denervation also shifted the threshold of the hypoxic ventilatory response but had no effect on the slope of either the hypoxic or hypercapnic ventilatory responses. Chronic exposure (2-12 months) to hypoxic-hypercapnic conditions (16% O2, 4% CO2) resulted in a sustained increase in ventilation. Initial increases in both tidal volume (VT) and breathing frequency (fR) were followed by a subsequent further increase in VT and concomitant decrease in fR (acclimation) which had little overall effect on ventilation (VE) but further increased calculated alveolar ventilation (VA). Respiratory sensitivity to hypoxia and hypercapnia were unaltered under these conditions. On acute return to breathing room air, VE remained elevated (approximately 35%) compared to control animals suggesting that deacclimation takes time. Carotid body denervation in these animals had similar effects to those seen in control animals suggesting that acclimation did not involve changes in carotid body input.
C L Webb; W K Milsom
Related Documents :
7875136 - Hyperventilation-induced changes of blood cell counts depend on hypocapnia.
3918476 - Ventilatory response during halothane and enflurane anaesthesia.
8308746 - Long-term modulation of the exercise ventilatory response in goats.
8516266 - Ventilation, co2 production, and co2 exposure effects in conscious, restrained cf-1 mice.
23108436 - Effects of core instability strength training on trunk muscle strength, spinal mobility...
7087196 - Effects of verapamil on exercise performance in chronic angina pectoris.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiration physiology     Volume:  98     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1995-02-09     Completed Date:  1995-02-09     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  137-52     Citation Subset:  IM; S    
Department of Zoology, University of British Columbia, Vancouver, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acute Disease
Anoxia / physiopathology*
Carotid Body / physiopathology*
Chronic Disease
Hypercapnia / physiopathology*
Oxygen / administration & dosage
Respiration / physiology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Ontogeny of the O2-sensitive pathway in medulla oblongata of postnatal rat.
Next Document:  Limited capacity for glyconeogenesis from alanine by diaphragm muscle.