Document Detail

Ventilatory response to carbon dioxide in term infants after halothane and nitrous oxide anesthesia.
MedLine Citation:
PMID:  8498659     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to determine whether the ventilatory response to CO2 is depressed in term infants after halothane and N2O anesthesia. Ventilatory response to CO2 was determined by using a maskless CO2 response test in which a ventilation ratio is calculated from measurements of transcutaneous PCO2 (PtcCO2). Ventilation ratio represents the fractional increase in ventilation that occurs in response to inspired CO2. Eight infants were studied who were at least 36 wk gestational age and 12 +/- 4 wk postnatal age, did not have apnea in the perioperative period (values are means +/- SD). Ventilation ratio measured with a 4%-inspired-CO2 stimulus increased significantly after anesthesia (3.5 +/- 0.8 vs 3.0 +/- 0.5, P = 0.02). Baseline PtcCO2 was significantly lower after anesthesia than before anesthesia (37 +/- 4 vs 42 +/- 3, P < 0.01) which may reflect the development of a relative metabolic acidosis. (The occurrence of postoperative metabolic acidosis was in fact documented in another group of eight infants.) Ventilatory response to CO2 was not depressed after halothane and nitrous oxide anesthesia in these term and near-term infants.
B W Palmisano; M A Setlock; M K Doyle; D R Rosner; G M Hoffman; J E Eckert
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  76     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-06-24     Completed Date:  1993-06-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1234-7     Citation Subset:  AIM; IM    
Department of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226.
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MeSH Terms
Anesthesia, Inhalation*
Carbon Dioxide / pharmacology*
Nitrous Oxide*
Respiration / drug effects*,  physiology
Surgical Procedures, Operative
Reg. No./Substance:
10024-97-2/Nitrous Oxide; 124-38-9/Carbon Dioxide; 151-67-7/Halothane
Comment In:
Anesth Analg. 1994 Apr;78(4):814-5   [PMID:  8135414 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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