Document Detail

Ventilatory response to CO2 and O2 near eupnea in awake dogs.
MedLine Citation:
PMID:  3139619     Owner:  NLM     Status:  MEDLINE    
The problem faced in determining the ventilatory response to CO2 near eupnea has been the difficulty of unloading metabolically produced CO2 from the subject in the steady state. Previous methods using extracorporeal circuits to unload CO2 are technically difficult and provide a limited number of experimental states per experiment. Using the method of high-frequency ventilation to unload CO2, we were able to obtain a large number of determinations in the same subject under conditions of hypoxia, normoxia, and hyperoxia. Data collected in five awake dogs show that the ventilatory response to CO2 is linear down to apnea during normoxic conditions but exhibits nonlinear behavior dependent on the level of arterial O2 tension. During hyperoxic conditions, the response was concave curvilinear, with a statistically significant decrease in slope near apnea. In contrast, mild hypoxia led to a convex curvilinear response with an increased slope near apnea.
W W Hwang; S M Yamashiro; D Sedlock; F S Grodins
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  65     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-11-22     Completed Date:  1988-11-22     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  788-96     Citation Subset:  IM    
Department of Biomedical Engineering, University of Southern California, Los Angeles 90089-1451.
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MeSH Terms
Anoxia / physiopathology
Apnea / physiopathology
Blood Pressure
Carbon Dioxide / blood,  physiology*
Dogs / physiology*
High-Frequency Ventilation
Oxygen / physiology*
Grant Support
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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