| Ventilatory patterns following burn injury and effect of sulfamylon. | |
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MedLine Citation:
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PMID: 1152087 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Seven burn patients treated with silver nitrate dressings were studied during the first 10 days after injury. Minute ventilation, oxygen consumption, and ventilatory equivalent were measured. Minute ventilation was increased two- to threefold, as was oxygen consumption. Ventilatory equivalent was only slightly increased. THree patients were initially treated with silver nitrate, and then, when clinically stable, were switched to Sulfamylon. They showed a 50% rise in ventilation, tidal volume, ventilatory equivalent, and a slight increase in respiratory rate and VD/VT. In addition, their PO2 increased and base excess fell. Five normal subjects were then given Diamox, and their minute ventilation, O2 consumption, and ventilatory equivalent were measured at rest, with a standard exercise, and with an added dead space. Diamox produced only a 25% increase in minute ventilation and ventilatory equivalent. The results suggest that, although some of the increased ventilation of Sulfamylon is due to carbonic anhydrase inhibition, another factor, such as pain casued by the topical agent, also plays a role. |
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Authors:
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P A Petroff; E W Hander; A D Mason |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Journal of trauma Volume: 15 ISSN: 0022-5282 ISO Abbreviation: J Trauma Publication Date: 1975 Aug |
Date Detail:
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Created Date: 1975-11-06 Completed Date: 1975-11-06 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0376373 Medline TA: J Trauma Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 650-6 Citation Subset: AIM; IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetazolamide
/
pharmacology,
therapeutic use Acid-Base Equilibrium / drug effects Adolescent Adult Bandages Burns / complications*, drug therapy, physiopathology Carbon Dioxide / biosynthesis Carbonic Anhydrase Inhibitors / pharmacology Humans Mafenide / therapeutic use* Male Oxygen / blood Oxygen Consumption / drug effects Physical Exertion Respiration* / drug effects Respiratory Dead Space / drug effects Silver Nitrate / pharmacology, therapeutic use Sulfonamides / therapeutic use* Tidal Volume Vital Capacity / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Carbonic Anhydrase Inhibitors; 0/Sulfonamides; 124-38-9/Carbon Dioxide; 138-39-6/Mafenide; 59-66-5/Acetazolamide; 7761-88-8/Silver Nitrate; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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