Document Detail

Ventilatory patterns following burn injury and effect of sulfamylon.
MedLine Citation:
PMID:  1152087     Owner:  NLM     Status:  MEDLINE    
Seven burn patients treated with silver nitrate dressings were studied during the first 10 days after injury. Minute ventilation, oxygen consumption, and ventilatory equivalent were measured. Minute ventilation was increased two- to threefold, as was oxygen consumption. Ventilatory equivalent was only slightly increased. THree patients were initially treated with silver nitrate, and then, when clinically stable, were switched to Sulfamylon. They showed a 50% rise in ventilation, tidal volume, ventilatory equivalent, and a slight increase in respiratory rate and VD/VT. In addition, their PO2 increased and base excess fell. Five normal subjects were then given Diamox, and their minute ventilation, O2 consumption, and ventilatory equivalent were measured at rest, with a standard exercise, and with an added dead space. Diamox produced only a 25% increase in minute ventilation and ventilatory equivalent. The results suggest that, although some of the increased ventilation of Sulfamylon is due to carbonic anhydrase inhibition, another factor, such as pain casued by the topical agent, also plays a role.
P A Petroff; E W Hander; A D Mason
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of trauma     Volume:  15     ISSN:  0022-5282     ISO Abbreviation:  J Trauma     Publication Date:  1975 Aug 
Date Detail:
Created Date:  1975-11-06     Completed Date:  1975-11-06     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0376373     Medline TA:  J Trauma     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  650-6     Citation Subset:  AIM; IM; S    
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MeSH Terms
Acetazolamide / pharmacology,  therapeutic use
Acid-Base Equilibrium / drug effects
Burns / complications*,  drug therapy,  physiopathology
Carbon Dioxide / biosynthesis
Carbonic Anhydrase Inhibitors / pharmacology
Mafenide / therapeutic use*
Oxygen / blood
Oxygen Consumption / drug effects
Physical Exertion
Respiration* / drug effects
Respiratory Dead Space / drug effects
Silver Nitrate / pharmacology,  therapeutic use
Sulfonamides / therapeutic use*
Tidal Volume
Vital Capacity / drug effects
Reg. No./Substance:
0/Carbonic Anhydrase Inhibitors; 0/Sulfonamides; 124-38-9/Carbon Dioxide; 138-39-6/Mafenide; 59-66-5/Acetazolamide; 7761-88-8/Silver Nitrate; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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