Document Detail

Ventilatory pattern and chest wall mechanics during ketamine anesthesia in humans.
MedLine Citation:
PMID:  3777478     Owner:  NLM     Status:  MEDLINE    
The effects of anesthetic doses of ketamine (iv bolus of 3 mg X kg-1 followed by a continuous infusion of 20 micrograms X kg-1 X min-1) on functional residual capacity (FRC) measured by the helium dilution method and on the breathing pattern recorded by a noninvasive method (NIM) based on chest wall circumference changes were studied in 14 ASA P.S. I patients. Ketamine anesthesia was associated with: 1) the maintenance of FRC, minute ventilation, and tidal volume; 2) an increase in rib cage contribution to tidal breathing; and 3) an alteration of volume-motion relationships of the chest wall compartments. It is concluded that: 1) in contrast to volatile anesthetic agents, ketamine anesthesia has a sparing effect on intercostal muscle activity, which may explain the maintenance of FRC; and 2) changes in chest wall geometry and compliance induced by anesthetic agents must be taken into account for NIM to be valid.
B Mankikian; J P Cantineau; R Sartene; F Clergue; P Viars
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anesthesiology     Volume:  65     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  1986 Nov 
Date Detail:
Created Date:  1986-11-28     Completed Date:  1986-11-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  492-9     Citation Subset:  AIM; IM    
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MeSH Terms
Anesthesia, Intravenous*
Functional Residual Capacity
Ketamine / pharmacology*
Lung Volume Measurements / standards
Respiration / drug effects*
Respiratory Muscles / drug effects
Thorax / drug effects*,  physiology
Tidal Volume
Reg. No./Substance:

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