Document Detail

Ventilatory management of acute respiratory distress syndrome: a consensus of two.
MedLine Citation:
PMID:  14707588     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To synthesize the emerging body of experimental, observational, and clinical trial data into a practical guideline for safe and effective ventilatory management of acute respiratory distress syndrome. DATA SOURCES: Relevant, peer-reviewed, scientific literature and personal observations from clinical practice. STUDY SELECTION: Relevant experimental studies and high-impact observational and clinical trials of acute respiratory distress syndrome management. DATA EXTRACTION: Detailed review of information contained in published scientific work. DATA SYNTHESIS: Interactive discussions between the authors that culminated in our consensus view of appropriate management. CONCLUSIONS: Prevention of ventilator-induced lung injury while accomplishing the essential life-supporting roles of mechanical ventilation is a complex undertaking that requires application of principles founded on a broad experimental and clinical database and on the results of well-executed clinical trials. At the bedside, execution of an effective lung-protective ventilation strategy remains an empirical process best guided by integrated physiology and a readiness to revise the management approach depending on the individual's response.
John J Marini; Luciano Gattinoni
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Critical care medicine     Volume:  32     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-01-06     Completed Date:  2004-02-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  250-5     Citation Subset:  AIM; IM    
University of Minnesota, Regions Hospital, St. Paul 55101, USA.
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MeSH Terms
Clinical Trials as Topic
Disease Models, Animal
Infant, Newborn
Practice Guidelines as Topic*
Respiration, Artificial / adverse effects,  standards*
Respiratory Distress Syndrome, Adult / diagnosis,  mortality,  therapy*
Respiratory Distress Syndrome, Newborn / diagnosis,  mortality,  therapy*
Risk Assessment
Survival Rate
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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