Document Detail

Ventilatory interaction between hypoxia and hypercapnia in piglets shortly after birth.
MedLine Citation:
PMID:  8023018     Owner:  NLM     Status:  MEDLINE    
In 12 piglets aged 0-1.5 days we assessed the relative contribution of the peripheral and central chemoreceptors in mediating the ventilatory response to CO2 at three levels of arterial O2 tension using the dynamic end-tidal forcing technique. With this technique the ventilatory response is separated into a peripheral and a central component using a two-compartment model. Each component is described by a CO2 sensitivity, a time constant, a transport time and a single apnoeic threshold. The results showed that the sensitivity of the peripheral chemoreceptors significantly (P < 0.01) increased from 25.0 +/- 23.6 (mean +/- SD) during normoxia (PaO2 = 12.8 +/- 0.3 kPa) to 42.5 +/- 29.4 during moderate hypoxia (PaO2 = 8.8 +/- 0.4 kPa) and to 80.2 +/- 44.4 at severe hypoxia (PaO2 = 5.1 +/- 0.3 kPa). There was no significant effect of the level of PaO2 on the other parameters. The results were compared with those obtained in a previous study in piglets aged 2-11 days. It showed that the interaction strength at the level of the peripheral chemoreceptors, defined as the negative ratio of the change in the peripheral CO2 sensitivity to the changes in PaO2 was greater in the younger piglets. From these results we conclude that in the newborn piglet the positive ventilatory interaction between hypoxia and hypercapnia at the level of the peripheral chemoreceptors is already developed shortly after birth and becomes smaller during development.
J G Wolsink; A Berkenbosch; J DeGoede; C N Olievier
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Respiration physiology     Volume:  96     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-08-02     Completed Date:  1994-08-02     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  25-35     Citation Subset:  IM; S    
Department of Physiology, University of Leiden, Netherlands.
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MeSH Terms
Animals, Newborn / physiology*
Anoxia / physiopathology*
Carbon Dioxide / pharmacology
Chemoreceptor Cells / physiology
Hypercapnia / physiopathology*
Respiration / physiology*
Swine / physiology*
Reg. No./Substance:
124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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