| Ventilatory interaction between hypoxia and [H+] at chemoreceptors of man. | |
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MedLine Citation:
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PMID: 240797 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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By measuring ventilation during isocapnic progressive hypoxia, peripheral chemoreceptor sensitivity to acute hypoxia (deltaV40) was measured in five normal young men under four sets of conditions: 1) at sea level at the subject's resting PCO2, 2) at sea level with PCO2 5 Torr above resting PCO2, 3) after 24 h at a simulated altitude of 4,267 m (PB = 447 Torr) at the subject's resting PCO2 measured during acute hyperoxia, and 4) after 24 h at high altitude, with PCO2 elevated to the subject's sea-level resting PCO2. With this experimental design, we were able to systematically vary the PCO2 and [H+] at the peripheral and central chemoreceptors of man. When mean pHa was decreased from 7.424 to 7.377 without significant change in PACO2, the mean deltaV40 increased from 18.0 to 55.9 1/min. Conversely, when mean PACO2 was altered between 33.8 and 41.6 Torr with pHa held relatively constant, the mean deltaV40 did not change. This suggests that it is the H+ and not CO2 which interacts with hypoxia in stimulating the ventilation of man. An additional finding was that the intrinsic sensitivity of the peripheral chemoreceptors to acute hypoxia did not change during 24 h of acclimatization to high altitude. |
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Authors:
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R A Gabel; R B Weiskopf |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of applied physiology Volume: 39 ISSN: 0021-8987 ISO Abbreviation: J Appl Physiol Publication Date: 1975 Aug |
Date Detail:
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Created Date: 1975-12-28 Completed Date: 1975-12-28 Revised Date: 2009-10-27 |
Medline Journal Info:
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Nlm Unique ID: 0376576 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 292-6 Citation Subset: IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Altitude Anoxia / physiopathology* Cations, Monovalent Chemoreceptor Cells / physiology* Environment, Controlled Humans Hydrogen* Hydrogen-Ion Concentration Hypercapnia / physiopathology Lung Volume Measurements Male Maximal Voluntary Ventilation Respiration* |
| Chemical | |
Reg. No./Substance:
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0/Cations, Monovalent; 1333-74-0/Hydrogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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