Document Detail


Ventilatory frequency variability in spontaneously breathing anaesthetized subjects.
MedLine Citation:
PMID:  10673869     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During spontaneous breathing general anaesthesia, inspiration is generally started by a signal related to preceding cardiovascular activity. This phenomenon, 'cardioventilatory coupling', contributes to the variation in ventilatory frequency. However, the detailed, breath-to-breath timing relationship between heart beat and inspiratory onset is complex, with at least four distinct patterns (designated patterns I-IV). These coupling patterns are defined according to the particular breath-to-breath change in: (a) entrainment ratio and (b) coupling interval, the interval between inspiratory onset and the preceding initiating heart beat. We have examined the relationship between coupling and timing of breathing in adult subjects breathing spontaneously during general anaesthesia. The heart rate-ventilatory frequency interaction was explored by identifying the distribution of different coupling patterns in a plot of heart rate vs ventilatory frequency (the HR/f plot) and analysing the variation in breathing frequency during each coupling pattern by differentiating between changes in entrainment ratio from changes in coupling interval. We observed that: (i) coupling patterns are distributed within specific regions of the HR/f plot; (ii) specific patterns of variation in breathing are associated with each coupling pattern; (iii) this variation is a consequence of the balance between changes in entrainment ratio and coupling interval; (iv) coupling was invariably present at low breathing frequencies; and (v) the inverse non-linear relationship between ventilatory frequency and variation is largely a consequence of changing coupling pattern with ventilatory frequency. Coupling explains much of the breath-to-breath variability of ventilatory frequency during anaesthesia, and may be relevant to the phenomena of hypoventilation, central apnoea and ventilatory arrhythmia. A hypothesis concerning the generation of coupling patterns is presented.
Authors:
D Galletly; P Larsen
Related Documents :
24341119 - Offering a smarter and brighter choice.
2096659 - Superposition of arteriolar vasomotion waves and regulation of blood flow in skeletal m...
8607309 - Heart rate variability and preoperative anxiety.
16973939 - Regular heartbeat dynamics are associated with cardiac health.
9626679 - System response of the sinoatrial node during vagal stimulation.
23438239 - Attentional biases for betel nut cues in heavy and light chewers.
7052549 - Latencies of chemically evoked discharges in human cutaneous nociceptors and of the con...
23178459 - Visible light-absorbing rhenium(i) tricarbonyl complexes as triplet photosensitizers in...
19880739 - The importance of color in mate choice of the blue crab callinectes sapidus.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  83     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1999 Oct 
Date Detail:
Created Date:  2000-03-02     Completed Date:  2000-03-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  552-63     Citation Subset:  IM    
Affiliation:
Section of Anaesthesia, Wellington School of Medicine, New Zealand.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Anesthesia, General*
Electrocardiography
Feedback / physiology
Female
Heart Rate / physiology*
Humans
Inhalation / physiology
Male
Middle Aged
Respiratory Mechanics / physiology*
Signal Processing, Computer-Assisted
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Refsum disease
Next Document:  A multicentre comparison of the costs of anaesthesia with sevoflurane or propofol.