Document Detail

Ventilatory effects of oxygen in the dog under thiopentone anaesthesia.
MedLine Citation:
PMID:  3355742     Owner:  NLM     Status:  MEDLINE    
The ventilatory effects of prolonged oxygen administration were examined in seven dogs during thiopentone anaesthesia. Ventilation, tidal volume (VT), ventilatory rate (f), minute ventilation (VE), inspiratory time (TI), expiratory time (TE), period (Ttot), TI/Ttot and mean inspiratory flow (VT/TI) were measured during the inhalation of room air, after 30 min of oxygen inhalation, and finally after a return to breathing room air. Arterial blood-gas tensions were measured before and after 5, 10, 20 and 30 min of oxygen administration and 15 min after return to breathing room air. Oxygen administration produced an immediate, significant and persistent decrease in ventilation, principally from a decrease in ventilatory rate and changes in ventilatory times. This was in contrast to what occurred in awake animals. Modifications in ventilatory mechanics or suppression of an hypoxic stimulus to ventilation were probably not involved. Anaesthesia may modify centrally mediated ventilatory responses to hyperoxia.
J H Gaudy; J F Sicard; J F Boitier
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  60     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-05-25     Completed Date:  1988-05-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  456-60     Citation Subset:  IM    
Département d'Anesthésie-Réanimation, Hôpital Rothschild, Paris.
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MeSH Terms
Anesthesia, Intravenous*
Depression, Chemical
Oxygen / pharmacology*
Respiration / drug effects*
Time Factors
Reg. No./Substance:
76-75-5/Thiopental; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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