Document Detail

Ventilatory effects of the nonimmobilizer 1,2-dichlorohexafluorocyclobutane (2N) in swine.
MedLine Citation:
PMID:  9428874     Owner:  NLM     Status:  MEDLINE    
Nonimmobilizers (inhaled compounds that do not suppress movement in response to a noxious stimulus) resemble anesthetics in their capacity to suppress memory, but unlike anesthetics, they can cause convulsions. Higher concentrations of nonimmobilizers may cause death, even with apparent suppression of convulsions by the concurrent administration of conventional inhaled anesthetics. We hypothesized that nonimmobilizers can depress ventilation and can cause death by adding to the depression of ventilation produced by conventional anesthetics. To test these hypotheses, we administered 1,2-dichlorohexafluorocyclobutane (2N) to four pigs anesthetized with desflurane. The addition of 2N decreased PaCO2 and tended to increase the slope of the ventilatory response to imposed increases in PETCO2. Limited results from study of two other nonimmobilizers (2,3-dichlorooctafluorobutane and perfluoropentane), in two pigs each, were consistent with the findings for 2N. However, experimental limitations (e.g., toxicity of 2,3-dichlorooctafluorobutane, and hypoxia from perfluoropentane) confound interpretation of these latter results. Our findings do not support our hypotheses--2N (and presumably all nonimmobilizers) seems to be a respiratory stimulant, not a depressant. Implications: A new class of inhaled compounds, nonimmobilizers, allow tests of how inhaled anesthetics act. Nonimmobilizers may act like anesthetics (e.g., impair learning) or may not (e.g., do not prevent movement in response to a noxious stimulus). The present work shows that, unlike anesthetics,nonimmobilizers do not depress breathing.
E P Steffey; M J Laster; P Ionescu; E I Eger; N Emerson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  86     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-01-29     Completed Date:  1998-01-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  173-8     Citation Subset:  AIM; IM    
Department of Anesthesia, University of California-San Francisco 94143-0464, USA.
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MeSH Terms
Anesthetics / pharmacology*
Blood Pressure / drug effects
Chlorofluorocarbons / pharmacology*
Cyclobutanes / pharmacology*
Respiration / drug effects*
Grant Support
Reg. No./Substance:
0/Anesthetics; 0/Chlorofluorocarbons; 0/Cyclobutanes; 356-18-3/1,2-dichloro-1,2,3,3,4,4-hexafluorocyclobutane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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