Document Detail

Ventilatory effects of almitrine bismesilate in dogs breathing normoxic, hyperoxic and hypoxic mixtures.
MedLine Citation:
PMID:  2305623     Owner:  NLM     Status:  MEDLINE    
The ventilatory effects of 1 i.v. almitrine were studied in five dogs anaesthetized with halothane 2% under conditions of normoxia, hyperoxia and hypoxia. Ventilation (minute ventilation, respiratory frequency, tidal volume, duration of inspiration and expiration, ratio TI/Ttot and VT/TI), Pao2, Paco2, pHa, systemic arterial pressure and heart rate were measured in air before and following almitrine; in air, after inhalation of pure oxygen and after almitrine in hyperoxia; in air, during hypoxia with Fio2 progressively decreased from 0.21 to 0.12 and after almitrine in hypoxia (FIO2 = 0.12). Halothane decreased ventilatory response to hypoxia. Almitrine stimulated ventilation irrespective of the level of oxygenation and restored the ventilatory response to hypoxia. Hyperoxia did not suppress ventilatory action of almitrine whose action is probably partly central. Hypoxia and almitrine did not induce major systemic haemodynamic modification.
J H Gaudy; J F Sicard; O Gateau
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  34     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-03-29     Completed Date:  1990-03-29     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  90-4     Citation Subset:  IM    
Laboratoire d'Anesthésiologie, Faculté de Médecine Saint-Antoine, Paris, France.
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MeSH Terms
Almitrine / pharmacology*
Anesthesia, Inhalation*
Oxygen / physiology*
Respiration / drug effects*
Stimulation, Chemical
Reg. No./Substance:
151-67-7/Halothane; 27469-53-0/Almitrine; 7782-44-7/Oxygen

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